Publications by authors named "Miguel C Lucena"
Article Synopsis
- Hypertensive individuals have a higher chance of developing chronic kidney disease (CKD), and managing proteinuria may be a potential treatment strategy.
- A study on spontaneously hypertensive rats revealed increased levels of -GlcNAcylation, a process linked to renal damage and proteinuria in high blood pressure conditions.
- Inhibiting GFAT, an enzyme involved in -GlcNAcylation, showed promise by reducing both -GlcNAcylation and proteinuria, indicating a novel mechanism related to hypertension-induced kidney issues.
Deregulated cellular metabolism is a hallmark of tumors. Cancer cells increase glucose and glutamine flux to provide energy needs and macromolecular synthesis demands. Several studies have been focused on the importance of glycolysis and pentose phosphate pathway.
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- Cancer cells require altered metabolism and nutrient uptake to maintain their harmful characteristics, particularly through pathways like the hexosamine biosynthetic pathway.
- This pathway produces important substrates that influence glycosylation, which plays a critical role in tumor growth and development.
- The review focuses on three specific types of glycosylation related to cancer progression and discusses potential inhibitors that could serve as anti-tumor treatments.
Growing evidences indicate that aberrant glycosylation can modulate tumor cell invasion and metastasis. The process termed "epithelial-mesenchymal transition" (EMT) provides a basic experimental model to shed light on this complex process. The EMT involves a striking decline in epithelial markers, accompanied by enhanced expression of mesenchymal markers, culminating in cell morphology change and increased cell motility.
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