Publications by authors named "Miguel Brandao"

Article Synopsis
  • - Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with low survival rates, primarily treated through surgery and radiation, as highlighted by the Brazilian Society of Surgical Oncology's guidelines on its management.
  • - The consensus emphasizes the importance of comprehensive staging, including imaging techniques like PET or CT scans, and recommends that all potential MCC cases be evaluated by a multidisciplinary team, including discussions in tumor boards to prevent treatment delays.
  • - For early-stage patients (clinical stage I or II), local excision and sentinel lymph node biopsy are advised, while those with positive lymph nodes should receive radiation therapy, and advanced cases should consider participation in clinical trials for treatment options.
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Plastics are controversial due to their production from fossil fuels, emissions during production and disposal, potential toxicity, and leakage to the environment. In light of these concerns, calls to use less plastic products and move toward nonplastic alternatives are common. However, these calls often overlook the environmental impacts of alternative materials.

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The world's forests store large amounts of carbon (C), and growing forests can reduce atmospheric CO by storing C in their biomass. This has provided the impetus for world-wide tree planting initiatives to offset fossil-fuel emissions. However, forests interact with their environment in complex and multifaceted ways that must be considered for a balanced assessment of the value of planting trees.

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Bioenergy has the potential to substitute the current demand for fossil fuels in various applications. Recovering energy from bio-based materials due to environmental considerations has been adopted as a policy objective by governments and international organizations, which led to both vast financial investment and scientific research, especially in the last two decades. So far, various feedstocks and technologies have been scrutinised by the research community, although not all of them are commercially adopted due to sustainability considerations.

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Climate change poses a remarkable challenge to global food security, for which wheat is one of the main staple agricultural commodities. The cultivation of different varieties of winter wheat in Galicia (commercial and native) under rotation systems with potato, maize and oilseed rape was evaluated from an environmental point of view. The general approach of this study included the gathering of the inventory data of the different crops, the quantification of their environmental impacts and economic benefits, to identify the best land management system.

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The number of publications on environmental footprint indicators has been growing rapidly, but with limited efforts to integrate different footprints into a coherent framework. Such integration is important for comprehensive understanding of environmental issues, policy formulation and assessment of trade-offs between different environmental concerns. Here, we systematize published footprint studies and define a family of footprints that can be used for the assessment of environmental sustainability.

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Land-use change (LUC) in Brazil has important implications on global climate change, ecosystem services and biodiversity, and agricultural expansion plays a critical role in this process. Concerns over these issues have led to the need for estimating the magnitude and impacts associated with that, which are increasingly reported in the environmental assessment of products. Currently, there is an extensive debate on which methods are more appropriate for estimating LUC and related emissions and regionalized estimates are lacking for Brazil, which is a world leader in agricultural production (e.

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The Brazilian Gastrointestinal Tumor Group developed guidelines for the surgical and clinical management of patients with billiary cancers. The multidisciplinary panel was composed of experts in the field of radiology, medical oncology, surgical oncology, radiotherapy, endoscopy and pathology. The panel utilized the most recent literature to develop a series of evidence-based recommendations on different treatment and diagnostic strategies for cholangiocarcinomas and gallbladder cancers.

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Aims: The aim of this study is to confirm the function of tumor-infiltrating lymphocytes (TILs) in sentinel lymph node (SLN) metastasis.

Materials And Methods: This retrospective study included 633 patients with invasive melanoma who underwent sentinel lymph node biopsy in 7 referral centers certified by the Brazilian Melanoma Group. Independent risk factors of sentinel node metastasis (SNL) were identified by multiple logistic regression.

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The etiology and pathogenesis of lentiginous acral melanomas are poorly understood. Recent studies have postulated that DNA repair mechanisms and cell growth pathways are involved in the development of melanoma, particularly changes in the MAPK pathways (RAS, BRAF, MEK 1/2, and ERK 1/2). The aim of this study is to assess the status of the MAP kinase pathways in the pathogenesis of acral melanomas.

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