Publications by authors named "Miguel Boland"
Improving axial resolution in Structured Illumination Microscopy using deep learning.
Philos Trans A Math Phys Eng Sci
June 2021
Article Synopsis
- Structured Illumination Microscopy (SIM) allows for imaging of biological structures below conventional optical limits, and recent advances in deep learning significantly enhance this technique's capabilities.
- The study presents a new method for reconstructing 3D SIM image stacks, achieving double the axial resolution compared to traditional SIM methods while remaining resilient to noise.
- Future adaptations to this method are discussed, with an aim to further push the boundaries of imaging resolution in biological research.
Comprehensive, high-quality reference genomes are required for functional characterization and taxonomic assignment of the human gut microbiota. We present the Unified Human Gastrointestinal Genome (UHGG) collection, comprising 204,938 nonredundant genomes from 4,644 gut prokaryotes. These genomes encode >170 million protein sequences, which we collated in the Unified Human Gastrointestinal Protein (UHGP) catalog.
View Article and Find Full Text PDFMGnify (http://www.ebi.ac.
View Article and Find Full Text PDFThe composition of the human gut microbiota is linked to health and disease, but knowledge of individual microbial species is needed to decipher their biological roles. Despite extensive culturing and sequencing efforts, the complete bacterial repertoire of the human gut microbiota remains undefined. Here we identify 1,952 uncultured candidate bacterial species by reconstructing 92,143 metagenome-assembled genomes from 11,850 human gut microbiomes.
View Article and Find Full Text PDF