Optimization of ultrasound-assisted extraction of polyphenols from globe artichoke (Cynara scolymus L.) bracts residues using response surface methodology.

Background: The globe artichoke (Cynara scolymus L.) is a rich source of phenolic compounds which may be extracted by ultrasound technology and used as a medicinal alternative. The objective of this work was to determine the radiation amplitude (%), ethanol concentration (%), and time extraction (min) required to guarantee an elevated content of polyphenol compounds.