Publications by authors named "Miguel Angel Orrego"
PLoS Negl Trop Dis
March 2015
Article Synopsis
- Cysticidal treatment for neurocysticercosis leads to significant inflammation around the cysts, causing neurological symptoms like seizures in both humans and pigs infected with Taenia solium.
- In a study comparing treated and untreated infected pigs, inflammation scores were higher in cysts that exhibited blood-brain barrier dysfunction (indicated by Evans blue staining) than those that didn't, particularly 120 hours after treatment.
- The research shows that this inflammatory response involves increased levels of proinflammatory genes and changes in regulatory markers, suggesting that treatments may enhance both inflammation and healing processes in the surrounding brain tissue.
Exp Parasitol
August 2013
Article Synopsis
- * In a study, 11 naturally infected pigs were injected with the dye Evans Blue to assess the blood-brain barrier disruption caused by Taenia solium cysts.
- * Results showed that pigs treated with anthelmintics before the dye infusion had more cysts with stained capsules, suggesting that the treatment increased inflammation and blood-brain barrier compromise, making this model valuable for studying treatment effects in neurocysticercosis.
