Centromeric AA motif in KIR as an optimal surrogate marker for precision definition of alloimmune reproductive failure.

Throughout pregnancy, the decidua is predominantly populated by NK lymphocytes expressing Killer immunoglobulin-like receptors (KIR) that recognize human leukocyte antigen-C (HLA-C) ligands from trophoblast cells. This study aims to investigate the association of KIR-HLA-C phenotypes in couples facing infertility, particularly recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF), in comparison to a reference population and fertile controls. This observational, non-interventional retrospective case-control study included patients consecutively referred to our Reproductive Immunology Unit from 2015 to 2019.

Characterization of the novel HLA-DRB1*10:38 allele, showing an extended cytoplasmic tail.

Sequence and expression analysis of the HLA-DRB1*10:38 allele.

Coronavirus-19 disease risk and protective factors associated with HLA/KIR polymorphisms in Ecuadorian patients residing in Madrid.

Background: Immigrants represented 21.8% of cases in a Spanish cohort of hospitalised patients with COVID-19, a proportion exceeding the percentage of immigrants in that area's total population. Among the ethnic-related genetic risk factors for COVID-19, human leukocyte antigen (HLA) genotypes in diverse populations might bias the response to SARS-CoV-2 infection and/or progression.

Identification of six novel HLA alleles, HLA-A*31:208, -B*08:306, -C*03:582, -C*04:494, -C*18:18 and -DRB1*07:133.

Characterization of six novel HLA alleles by next-generation sequencing.

Full-length characterization of the HLA-DQB1*03:25:01 allele in two Amerindian individuals.

Genomic full-length characterization of the HLA-DQB1*03:25:01 allele.

Genomic full-length confirmatory sequence of HLA-DQB1*04:59N allele in three Colombian individuals.

The extended genomic sequence of HLA-DQB1*04:59N allele.

Sequencing of two novel HLA class I null alleles, A*32:160N and B*14:113N, produced by single-nucleotide mutations.

Characterization of two novel HLA class I null alleles.

Sequencing of a novel HLA-DQB1 allele, DQB1*04:02:01:16Q, with a mutation in the intron 3 donor splicing site.

The novel HLA-DQB1*04:02:01:16Q allele showing a point mutation in the intron 3.

Characterization of six novel HLA alleles, HLA-a*24:565, -a*29:160, -b*07:444, -b*57:156, -c*18:15 and -DPB1*795:01:02.

Six novel HLA alleles were characterized in the Spanish population.

The novel HLA-C*07:1000 allele was likely generated by an intragenic recombination event.

Characterization of the novel HLA-C allele, HLA-C*07:1000.

Characterization of novel HLA class I alleles: HLA-A*02:984, -B*18:205, -B*57:142N, -C*02:204, and -C*16:185.

Five new HLA class I alleles were characterized by next-generation sequencing.