Publications by authors named "Miguel Angel Moran"
Article Synopsis
- The study investigates the effectiveness of various antibiotics against a multidrug-resistant Gram-negative bacillus in critically ill patients, using a pharmacokinetic/pharmacodynamic (PK/PD) framework.
- Antibiotics evaluated included cotrimoxazole, levofloxacin, minocycline, tigecycline, cefiderocol, and a new combination of aztreonam/avibactam, with Monte Carlo simulations used to assess treatment probabilities and outcomes.
- Findings suggested that cefiderocol, minocycline, tigecycline, and aztreonam/avibactam were promising treatments, but revealed inconsistencies between established PK/PD breakpoints and clinical guidelines, especially depending on isolation location.
Background: The high effectiveness and safety of the two-drug (2DRs) strategy using dolutegravir (DTG) plus lamivudine (3TC) have led to international guidelines recommending their use for treatment-naive HIV patients. In virologically suppressed patients, de-escalating from 3DRs to DTG plus either rilpivirine (RPV) or 3TC has shown high rates of virological suppression.
Objectives: This study aimed to compare the real-life data of two multicenter Spanish cohorts of PLWHIV treated with DTG plus 3TC (SPADE-3) or RPV (DORIPEX) as a switch strategy, not only in terms of virological suppression, safety, and durability but also in terms of immune restoration.
Dolutegravir (DTG) based dual therapies for treating PLWHIV are a standard of care nowadays. Switching to DTG and lamivudine (3TC) safety and efficacy were proven in TANGO randomized clinical trial. This multicenter retrospective study included 1032 HIV virologically suppressed patients switching to DTG+3TC from 13 Spanish hospitals.
View Article and Find Full Text PDFAfter SARS-CoV-2 infection, the molecular phenoreversion of the immunological response and its associated metabolic dysregulation are required for a full recovery of the patient. This process is patient-dependent due to the manifold possibilities induced by virus severity, its phylogenic evolution and the vaccination status of the population. We have here investigated the natural history of COVID-19 disease at the molecular level, characterizing the metabolic and immunological phenoreversion over time in large cohorts of hospitalized severe patients (n = 886) and non-hospitalized recovered patients that self-reported having passed the disease (n = 513).
View Article and Find Full Text PDFSwitching dual therapy with dolutegravir (DTG) plus rilpivirine (RPV) was assessed in the SWORD-1 and SWORD-2 studies. Real-life data regarding the immunological impact of this approach on CD4+ and CD8+ T lymphocyte counts and the CD4/CD8 ratio are scarce. We evaluated this strategy on the basis of clinical practice data.
View Article and Find Full Text PDFObjective: The aim of this study was to analyse the relationship between glucocorticoids and damage accrual in SLE.
Methods: We report an observational cohort study including 230 patients with SLE enrolled at diagnosis with 5 years of follow-up. Damage was calculated using the SLICC damage index.