Publications by authors named "Miguel Angel Martin-Rey"
Article Synopsis
- BCR-JAK2 is a rare gene fusion linked to various types of leukemia that do not involve the Philadelphia chromosome; this study shows that its expression in mice causes severe cancer development.
- Transplanting bone marrow with BCR-JAK2 leads to enlarged spleens, excessive white blood cells, and the presence of immature myeloid cells in the blood, indicating serious blood-related issues.
- The findings suggest that BCR-JAK2 promotes leukemia by disrupting normal cell death processes, which may help in creating new targeted treatments for Philadelphia chromosome-negative leukemia.
