Association between CYP4A11 and EPHX2 genetic polymorphisms and chronic kidney disease progression in hypertensive patients.

Background: There are evidence indicating that some metabolites of arachidonic acid produced by cytochromes P450 (CYP) and epoxide hydroxylase (EPHX2), such as hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs) or dihydroxyeicosatrienoic acids (DHETEs), play an important role in blood pressure regulation and they could contribute to the development of hypertension (HT) and kidney damage. Therefore, the main aim of the study was to evaluate whether the genetic polymorphisms of CYP2C8, CYP2C9, CYP2J2, CYP4F2, CYP4F11 and EPHX2, responsible for the formation of HETEs, EETs and DHETEs, are related to the progression of impaired renal function in a group of patients with hypertension.

Methods: 151HT patients from a hospital nephrology service were included in the study.

Frequency of Promoter Variable Number Tandem Repeat Polymorphism in a Spanish Population: Linkage Disequilibrium with Allele.

Background: A promoter variable number tandem repeat polymorphism (pVNTR) of is described with three types of fragments: short (), medium () and long (). The allele reduces the mRNA level in the human liver, and it was found to be in high linkage disequilibrium (LD) with the allele in a White American population. The aim of the present study is to determine the presence and frequency of in a Spanish population, as well as analyzing whether the allele is in LD with the allele in this population.

Prevalence of Potential Drug-Drug Interaction Risk among Chronic Kidney Disease Patients in a Spanish Hospital.

Chronic kidney disease (CKD) is a major health problem worldwide and, in Spain, it is present in 15.1% of individuals. CKD is frequently associated with some comorbidities and patients need to be prescribed multiple medications.