Effect of chronic exposure to lead on estrogen action in the prepubertal rat uterus.

Lead is a widely spread environmental pollutant known to affect both male and female reproductive systems in humans and in experimental animals. The present study investigated the effect of a chronic exposure to lead on different parameters of estrogen stimulation in the uteri of prepubertal rats. Chronic exposure to lead enhanced some parameters of estrogen stimulation, inhibited other estrogenic responses, while the remainder were unaltered.