Publications by authors named "Miguel A Casado"
Introduction: A significant percentage of patients coinfected with hepatitis B virus (HBV) and hepatitis D virus (HDV) are undiagnosed. Coinfected patients progress to advanced liver disease faster than HBV monoinfected patients, thereby consuming more healthcare resources. The aim was to perform an analysis to determine the cost of hidden HDV infection in Spain.
View Article and Find Full Text PDFPenile prosthesis (PP) implantation is feasible as an outpatient surgery. The present study describes the surgical process and establishes a consensus for improving the care circuit for outpatient PP implantation in Spain. A working group composed of a scientific committee with extensive experience in PP implantation and representatives of important scientific societies reached a consensus about the recommendations for outpatient PP implantation.
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- * Using an economic model, the study projected lifetime liver complications and costs for both treatments in a hypothetical cohort of 3,882 CHD patients, focusing on serious complications like decompensated cirrhosis, hepatocellular carcinoma, and death.
- * Results showed that bulevirtide significantly reduced complications and associated costs by approximately €11.8 million compared to PEG-IFN-α, suggesting it is a more efficient treatment option
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- The study aims to assess the economic impact of major eye diseases (glaucoma, diabetic retinopathy, diabetic macular edema, age-related macular degeneration, and high myopia) leading to vision loss and blindness in Spain over a decade (2021-2030).
- A cost analysis model was created using existing data on disease prevalence, healthcare costs, and expert validation to estimate that by 2030, around 8 million patients will incur a total cost of 99.8 billion euros, with significant contributions from direct non-healthcare costs and loss of productivity.
- Glaucoma and diabetic eye diseases are projected to have the highest financial burdens, with costs surging dramatically for diabetes-related conditions, highlighting an urgent
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- This study looked at how a new treatment called axi-cel helps patients in Spain with a type of cancer after other treatments didn’t work.
- They compared its results to the old treatment, chemotherapy, using data from two different studies.
- The results showed that more people could live longer and have better quality of life if more patients could get access to axi-cel instead of just chemotherapy.
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- The study aimed to compare comorbidities and non-AIDS-related events between HIV-infected individuals and those with HIV/HCV coinfection in the context of modern therapies that don’t use interferon.
- A retrospective analysis of clinical records from Spanish patients revealed no significant differences in incidents of conditions like hypertension, diabetes, or cardiovascular disease between the two groups, suggesting that prior HCV exposure didn't impact health outcomes.
- Successful treatment of HCV with direct-acting antivirals (DAAs) showed promising results for improving health and survival rates in HIV/HCV-coinfected patients, emphasizing the need for early detection and treatment.
Perceived quality of life by patients with immune-mediated inflammatory diseases treated with biological therapies. SACVINFA study.
Farm Hosp
November 2024
Article Synopsis
- - The study aimed to assess the quality of life in patients with common immune-mediated inflammatory diseases in Spain (like IBD, psoriasis, RA, etc.) and identify factors affecting their quality of life.
- - Conducted in four hospitals in Madrid, this observational study analyzed 578 adult patients using various questionnaires to measure aspects like mobility, pain, and anxiety.
- - The results indicated that patients with psoriasis and inflammatory bowel disease had better quality of life scores compared to those with psoriatic arthritis and rheumatoid arthritis, and factors such as gender, disease severity, age, and treatment persistence significantly impacted quality of life.
Article Synopsis
- The introduction of sofosbuvir/velpatasvir (SOF/VEL-Epclusa®) marked a significant advancement in hepatitis C virus (HCV) treatment, demonstrating high cure rates in patients and aiding in HCV elimination efforts in Spain.
- A Markov model simulation analyzed the clinical and economic impact of SOF/VEL on 30,488 chronic HCV patients over five years, showing it had a much better sustained viral response rate of 98.9% compared to 61.0% with prior therapies.
- The results indicated that SOF/VEL significantly reduced liver complications and related healthcare costs, leading to savings of 197 million euros and lowering rates of severe outcomes like decompens
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- Hemophilia is a congenital disorder due to a lack of clotting factors VIII (in Hemophilia A) or IX (in Hemophilia B), leading to frequent bleeding, and its severity is classified based on baseline clotting factor levels.
- This study analyzed data from 288 adult patients in Spain with moderate to severe hemophilia, focusing on their economic and humanistic burden, using data from the CHESS II study (2018-2020).
- The findings revealed that severe hemophilia had significantly higher annual direct and indirect costs compared to moderate cases, with total costs averaging €91,017 for Hemophilia A and €163,924 for Hemophilia B, while health-related quality of life
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- * Hospital at Home (HaH) teams offer a new model for delivering oncologic therapies at home, which can complement traditional care and improve patient outcomes while alleviating hospital costs.
- * A panel of experts from various Spanish societies developed minimum recommendations for home-administered oncologic therapies through literature review and discussion, laying groundwork for future programs in Spain.
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- Many individuals with Hepatitis C virus (HCV) and Hepatitis B virus (HBV) infections are unaware of their conditions, especially vulnerable populations who struggle with access to healthcare; emergency departments often serve as their only healthcare point of contact.
- A study conducted in emergency departments tested over 17,500 adults for HBsAg and HCV antibodies, discovering a higher prevalence than in the general population, with a significant percentage of positive cases previously unaware of their infections and successfully linking many to care.
- The screening program demonstrated cost-effectiveness, notably in individuals aged 40-70 with HCV, suggesting that emergency department screenings could improve health outcomes and provide a cost-efficient intervention for viral hepatitis.
Chronic hepatitis D (CHD) is a severe form of viral hepatitis that leads to liver cirrhosis and hepatocellular carcinoma. CHD is underdiagnosed, and this study aimed to assess the impact of hepatitis D reflex testing in HBsAg-positive individuals in Spain over the next 8 years. Two scenarios were compared: the current situation (7.
View Article and Find Full Text PDFRecommendations for the management of yttrium-90 radioembolization in the treatment of patients with colorectal cancer liver metastases: a multidisciplinary review.
Clin Transl Oncol
April 2024
Article Synopsis
- The study focuses on the evolving treatment strategies for liver metastases from colon cancer, highlighting the role of Yttrium-90 Radioembolization (Y-90 TARE) as a viable option for patients with unresectable liver metastases.
- A multidisciplinary committee of experts conducted a thorough literature review to create recommendations on the use of Y-90 TARE, addressing criteria like patient selection, treatment indications, and potential contraindications.
- The review provides a detailed framework for implementing Y-90 TARE, covering essential areas from initial patient evaluation to post-treatment follow-up, ensuring comprehensive management of the treatment process.
A cost analysis of thiopurine treatment was carried out in 257 patients, with 153 preemptively genotyped for and 104 retrospectively genotyped in a Spanish setting. The healthcare cost was significantly higher in patients retrospectively genotyped compared to those who were preemptively genotyped ( < 0.001).
View Article and Find Full Text PDFObjective: To determine, using the Delphi method, standardized recommendations for the follow-up of patients undergoing an interventional procedure for the treatment of chronic pain in Spain.
Methods: First, a systematic literature review was performed to identify the literature on the management of patients with chronic pain undergoing interventional techniques; subsequently, a two-round Delphi survey with 108 questions was conducted. The questionnaire was validated by a Scientific Committee (5 experts) and sent to 47 experts specialized in chronic pain.
Objective: To determine the economic impact of the incremental consumption of resources for the diagnosis and treatment of anastomotic leak (AL) in patients after resection with anastomosis for colorectal cancer compared to patients without AL on the Spanish health system.
Method: This study included a literature review with parameters validated by experts and the development of a cost analysis model to estimate the incremental resource consumption of patients with AL versus those without. The patients were divided into three groups: 1) colon cancer (CC) with resection, anastomosis and AL; 2) rectal cancer (RC) with resection, anastomosis without protective stoma and AL; and 3) RC with resection, anastomosis with protective stoma and AL.
Article Synopsis
- - The study evaluated the effectiveness of Sofosbuvir (SOF)-based treatments for chronic hepatitis C in Spain from 2015-2019, showing improved patient outcomes compared to older therapies like peginterferon and ribavirin.
- - SOF-based regimens yielded a sustained virological response (SVR) of 93-98% and significantly reduced complications such as decompensated cirrhosis (by 89%) and liver-related mortality (by 82%), while also providing substantial cost savings.
- - Overall, the findings support SOF-based treatments as a cost-effective solution that enhances health outcomes for HCV patients in Spain, aligning with global health objectives set by the WHO.
The Spanish Society of Digestive Pathology (SEPD), the Spanish Association for the Study of the Liver (AEEH), the Spanish Society of Infections and Clinical Microbiology (SEIMC) and its Viral Hepatitis Study Group (GEHEP), and with the endorsement of the Alliance for the Elimination of Viral Hepatitis in Spain (AEHVE), have agreed on a document to carry out a comprehensive diagnosis of viral hepatitis (B, C and D), from a single blood sample; that is, a comprehensive diagnosis, in the hospital and/or at the point of care of the patient. We propose an algorithm, so that the positive result in a viral hepatitis serology (B, C and D), as well as human immunodeficiency virus (HIV), would trigger the analysis of the rest of the virus, including the viral load when necessary, in the same blood draw. In addition, we make two additional recommendations.
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- The study aimed to analyze the experiences of breast and lung cancer patients at a Spanish hospital using both qualitative interviews and quantitative surveys.
- Six phases of the patient journey were identified, including "my life before diagnosis," "discovery," "initiation," "treatment," "follow-up," and "my current life," with notable differences in experiences across these phases.
- The Net Promoter Score indicated a general satisfaction rate of 46%, with 60% of patients expressing they were promoters of the hospital's services.
Medicine and technology are constantly evolving. The COVID-19 pandemic has accelerated the development of digitalization in the health sector and specifically of telemedicine. Through a structured bibliographic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) methodology, in this study, the concepts related to telemedicine, its application and the legal regulatory context are defined.
View Article and Find Full Text PDFEvaluation of the hospital care quality perceived by patients with immune-mediated inflammatory diseases from the pharmacy service. SACVINFA study.
J Clin Pharm Ther
December 2022
Article Synopsis
- The study evaluates patient satisfaction with healthcare among individuals suffering from prevalent immune-mediated inflammatory diseases (IMIDs) in Spain, specifically focusing on conditions like inflammatory bowel disease (IBD), psoriasis (Ps), psoriatic arthritis (PsA), rheumatoid arthritis (RA), and spondyloarthropathies (SpAs).
- Conducted in four hospitals within the Community of Madrid, the research involved 578 adult patients using questionnaires to assess their experiences and health-related quality of life.
- Results indicated a general satisfaction score of 6.6 out of 10, with RA patients reporting the lowest satisfaction, while factors like productive interactions and patient self-management received higher scores in terms of healthcare experience.
Background And Aims: Management of inflammatory bowel disease [IBD] is complex and IBD Comprehensive Care Units [ICCUs] facilitate the delivery of quality care to IBD patients. The objective of this study was to update the existing set of quality indicators [QIs] for ICCUs, based on a nationwide quality certification programme carried out in Spain, from a multi-stakeholder perspective and using multicriteria decision analysis [MCDA] methodology.
Methods: An MCDA comprising three different phases was conducted.
Reaction of an amido pincer complex [(CNC)*Rh(CO)] () (CNC* is the deprotonated form of CNC) with carbon dioxide gave a neutral complex [(CNC-CO)*Rh(CO)] (), which is the result of a C-C bond-forming reaction between the deprotonated arm of the CNC* ligand and CO. The molecular structure of showed a zwitterionic complex, where the CO moiety is covalently connected to the former ═CH arm of the CNC* pincer ligand. The unusual structure of allowed us to explore the reactivity of the CO moiety with selected primary amines RNH (benzylamine and ammonia), which afforded cationic complexes [(CNC)Rh(CO)][HRNC()O] (R = Bz (), H ()).
View Article and Find Full Text PDFThe study aimed to assess the cost-effectiveness of axicabtagene ciloleucel (axi-cel) vs. tisagenlecleucel (tisa-cel) for the treatment of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) after ≥2 lines of systemic therapy in Spain. A lifetime partitioned survival mixture cure model, which comprises pre-progression, post-progression, and death health states, was used to estimate the accumulated costs and outcomes in terms of life years gained (LYG) and quality-adjusted life years (QALY).
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