Publications by authors named "Miguel A Basante-Bedoya"
Ergosterol is a critical membrane lipid in fungi. In , this essential plasma membrane amphipathic lipid is important for interactions with host cells, in particular, host immune responses. Here, we use a live-cell reporter for specifically visualizing ergosterol and show that apical enrichment of this sterol is not critical for budding and filamentous growth in this human fungal pathogen.
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- Flippases in C. albicans, especially Drs2, are vital for lipid transport, maintaining membrane asymmetry, and enabling filamentous growth.
- Deleting drs2 not only makes the yeast susceptible to antifungals like fluconazole but also disrupts lipid distributions like PI(4)P and ergosterol.
- Manipulating other lipid transporters like Osh4 can partially compensate for Drs2's loss, but Drs2's role in membrane organization and localization is essential for resisting certain toxins and overall growth.