Publications by authors named "Miguchi M"
Objective: To investigate the incidence of male sexual dysfunction (SD) including erectile dysfunction (ErD) and ejaculatory dysfunction (EjD) after minimally invasive rectal cancer surgery.
Background: Male SD significantly affects post-rectal cancer surgery quality of life (QOL). Current assessments using the International Index of Erectile Function-5 are unsuitable for patients with reduced postoperative sexual activity, because it assumes sexual intercourse.
Article Synopsis
- The study investigates optimal colonoscopy surveillance intervals for Lynch syndrome cases by analyzing colorectal cancer incidence and precancerous lesions in a multicenter study conducted in Japan.
- Results show that advanced colorectal cancers are detected more frequently beyond a 2-year interval, with significant differences in detection rates between intervals.
- The findings suggest that regular colonoscopy surveillance within 2 years is crucial for early detection, with specific risk stratifications for different gene mutations indicating varying risks for subsequent colorectal cancers.
Article Synopsis
- The study investigated how preoperative gallbladder drainage affects surgical outcomes in patients with acute cholecystitis.
- A total of 221 patients were analyzed, comparing outcomes of those with no drainage, percutaneous drainage, and endoscopic drainage.
- Findings suggested that drainage method did not significantly influence operation time, blood loss, or complications, although the PTGBD group experienced longer hospital stays.
Article Synopsis
- Preoperative diagnosis of gallbladder amyloidosis can be challenging, but in this case, a patient showed symptoms like gallbladder dyskinesia that pointed towards this condition.
- A 59-year-old male with a history of multiple myeloma underwent imaging that revealed an enlarged gallbladder, and after further examination, he was diagnosed with gallbladder dyskinesia likely due to amyloidosis.
- The patient successfully underwent laparoscopic cholecystectomy, showing amyloid deposits upon histopathological examination, and was discharged without any recurrence of pain.
Background: Goblet cell adenocarcinoma is an extremely rare tumor in which the same cells exhibit both mucinous and neuroendocrine differentiation. It is considered more aggressive compared to conventional carcinoids and more likely to cause metastasis.
Case Presentation: We report a case of goblet cell adenocarcinoma with peritoneal metastases.
Introduction: The "weekday effect" on elective surgery remains controversial. We aimed to examine the association between the day of surgery and short-term outcomes after elective surgery for stage I-III colorectal cancer (CRC).
Methods: We performed a multicenter retrospective analysis of 2574 patients who underwent primary colorectal resection for CRC between January 2017 and December 2019 at 15 institutions belonging to the Hiroshima Surgical Study Group of Clinical Oncology.
Purpose: Several factors have been reported as risk factors for anastomotic leakage after resection of rectal cancer. This study aimed to evaluate the risk factors for anastomotic leakage, including nutritional and immunological indices, following rectal cancer resection.
Methods: This study used a multicenter database of 803 patients from the Hiroshima Surgical study group of Clinical Oncology who underwent rectal resection with stapled anastomosis for rectal cancer between October 2016 and April 2020.
Purpose: There is no consensus on the safety and effectiveness of adjuvant chemotherapy for patients with stage III colorectal cancer (CRC) aged ≥ 80 years. We conducted a prospective multi-institutional phase II study of uracil-tegafur and leucovorin (UFT/LV) as adjuvant chemotherapy in this population.
Patients And Methods: Patients with stage III CRC aged ≥ 80 years who underwent curative resection were enrolled.
Article Synopsis
- Colonoscopy surveillance is crucial for patients with Lynch syndrome to detect and remove adenomas, with recommendations for procedures every 1-2 years starting at age 20-25.
- A study of 309 patients showed a very high colonoscopy completion rate at 98.8% and low complication rates, although previous colorectal surgery was linked to higher completion rates.
- Results indicated that more experienced endoscopists had better adenoma detection rates, and longer intervals between colonoscopies (over 24 months) increased the risk of developing colorectal cancer.
Background/aim: We previously reported three items that preoperatively predicted complicated appendicitis (body temperature, C-reactive protein, and fluid retention around the appendix). In this study, we aimed to compare other predictors to confirm the usefulness of our predictors with those of previous reports on the items as predictors of complicated appendicitis preoperatively (criteria A which consist of 8 items, criteria B which consist of 7 items).
Patients And Methods: We retrospectively evaluated 417 adult patients who underwent surgery for acute appendicitis between January 2013 and December 2019 and compared our items with criteria A and criteria B according to the results of the area under the receiver operating characteristic curve (AUC), homogeneity, discriminatory ability, and Akaike information criterion (AIC).
Article Synopsis
- Complex factors, both genetic (like MMR gene mutations in Lynch syndrome) and environmental (such as alcohol consumption), may influence the risk and timing of colorectal cancer onset in patients.
- A study involving 288 patients with Lynch syndrome found that alcohol drinkers had a significantly higher risk of developing colorectal cancer earlier compared to non-drinkers.
- The increased risk was particularly notable in men, people with specific MMR gene mutations (MLH1 and MSH2), and those with tumors in the proximal colon, suggesting the need for alcohol reduction as a preventative measure.
Article Synopsis
- A 92-year-old man was hospitalized due to loss of consciousness, and a CT scan showed an intraperitoneal abscess that was drained.* -
- After the drainage, the fluid turned to intestinal juice, leading to surgery where a 1 cm perforation in the ileum was found.* -
- Despite surgery, the patient developed a high fever and was diagnosed with extranodal NK/T-cell lymphoma, but due to the condition's severity, further treatment was not possible, and he passed away 24 days later.*
Background: Sciatic hernias are rare pelvic floor hernias that occur through the sciatic foramen and often present as abdominal or pelvic pain, particularly in women. Historically, they were repaired using an open approach, with limited reports on their laparoscopic treatment.
Case Presentation: Here we present the case of an 85-year-old woman who had repeated abdominal pain and was referred to our hospital for sciatic hernia surgery after conservative treatment.
A 16-y-old Japanese female was referred to our hospital with a suspicion of infected retroperitoneal cyst. Abdominal CT MRI revealed a 38-mm diameter retroperitoneal cyst under the left diaphragm. Because a retroperitoneal bronchogenic cyst was suspected, total resection was planned.
View Article and Find Full Text PDFIntroduction: The number of elderly patients with colorectal cancer has gradually increased. Laparoscopic colorectal surgery is widely used to approach colorectal cancer. The aim of this study was to evaluate long-term outcomes in octogenarians who underwent laparoscopic colorectal surgery for colorectal cancer.
View Article and Find Full Text PDFBackground/aim: Right ventricular cardiac metastasis from colorectal cancer (CRC) is rare and clinically silent. There is no standardised treatment. To date, only twelve cases have been reported in the literature.
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- - FOLFOXIRI combined with bevacizumab is an effective first-line treatment for selected patients with untreated metastatic colorectal cancer (mCRC) with specific UGT1A1 genotypes, achieving an overall response rate (ORR) of 63.6%.
- - A study of 47 patients showed favorable outcomes with median treatment times, including 8.1 months for time to treatment failure and 34.4 months for overall survival, although significant adverse events like neutropenia were observed.
- - The results highlight the benefits of this treatment approach in a Japanese patient population, but suggest careful monitoring is needed due to the risk of serious side effects like febrile neutropenia.
Traumatic diaphragmatic hernia is a serious complication of blunt trauma to the abdomen or thorax. Although traumatic diaphragmatic hernia is treated with surgical repair, a laparoscopic approach is infrequently employed. Here we present the case of a 66-year-old man with a bruise on the left side of his back.
View Article and Find Full Text PDFWe herein report the first case of rectal stenosis that developed after internal hemorrhoid treatment with aluminum potassium sulfate and tannic acid (ALTA) therapy that was successfully treated by laparoscopic surgery. A 72-year-old man suffered from a fever and rectal stenosis after undergoing internal hemorrhoid treatment with a submucosal injection of ALTA at a previous clinic. Three months after ALTA therapy, he developed frequent mucous and bloody stools.
View Article and Find Full Text PDFBackground: Rectovaginal fistula (RVF) following aluminum potassium sulfate hydrate-tannic acid (ALTA) injection therapy for hemorrhoids is a rare complication. We report the first case of RVF after ALTA injection therapy successfully treated by gluteal-fold flap.
Case Presentation: A 49-year-old female suffered from a fever and rectal ulcer after undergoing internal hemorrhoid treatment with a submucosal ALTA injection at a previous clinic.
Article Synopsis
- BRAF mutations are prevalent in colorectal cancer (CRC), activating the MEK-MAPK pathway, but current treatments focusing solely on epidermal growth factor receptor are ineffective in these cases.
- Researchers used engineered mouse models to investigate gene expression in BRAF-mutated CRC and identified GREB1 as a significantly upregulated gene compared to wild-type and KRAS-mutated counterparts.
- Silencing GREB1 reduced CRC cell proliferation, while its overexpression increased it, indicating that GREB1 could be a promising therapeutic target for CRCs with BRAF mutations.
Article Synopsis
- - Rectal tumors are usually removed through proctectomy, which can negatively affect patients' quality of life due to complications like a permanent stoma and issues with urinary and sexual function.
- - A new combined procedure of local resection and endoscopic submucosal dissection for low rectal tumors shows promising results, based on four cases treated at Hiroshima City Asa Citizens Hospital, with no reported recurrences over 56 months.
- - This innovative approach achieved 100% successful resection rates while maintaining rectal function and minimizing postoperative complications, thus improving patient outcomes compared to traditional methods.