[The effect of lithium derivatives of GABA on blood circulation and metabolic indices in the brain under ischemia].

In acute experiments on anesthetized cats with cerebral ischemia in conditions of autohemoperfusion of cerebral and peripheral vessels with a stable volume of blood we found that lithium oxybutirate and new GABA derivatives: LOS 1-84 and LOS 5-79 affect the cerebral blood flow and metabolism in the brain. Prophylactic intravenous injection of lithium oxybutirate did not affect the development of postischemic hyperperfusion but inhibited postischemic hyperperfusion. The compounds prevent the development of postischemic phenomena and promote the recovery of metabolism in the brain.

[The role of the dopaminergic component in the autoregulatory reaction of the cerebral vessels].

Cerebral blood flow was measured in anesthetised white rats with the hydrogen clearance technique under different levels of arterial blood pressure before and after cerebral ischemia induced with the occlusion of the common carotid arteries during 12 min. The continuous i.v.