Dual inhibition of P38 MAPK and JNK pathways preserves stemness markers and alleviates premature activation of muscle stem cells during isolation.

Background: Adult skeletal muscle contains resident muscle stem cells (MuSC) with high myogenic and engraftment potentials, making them suitable for cell therapy and regenerative medicine approaches. However, purification process of MuSC remains a major hurdle to their use in the clinic. Indeed, muscle tissue enzymatic dissociation triggers a massive activation of stress signaling pathways, among which P38 and JNK MAPK, associated with a premature loss of MuSC quiescence.

Toward machine-assisted tuning avoiding the underestimation of uncertainty in climate change projections.

Documenting the uncertainty of climate change projections is a fundamental objective of the inter-comparison exercises organized to feed into the Intergovernmental Panel on Climate Change (IPCC) reports. Usually, each modeling center contributes to these exercises with one or two configurations of its climate model, corresponding to a particular choice of "free parameter" values, resulting from a long and often tedious "model tuning" phase. How much uncertainty is omitted by this selection and how might readers of IPCC reports and users of climate projections be misled by its omission? We show here how recent machine learning approaches can transform the way climate model tuning is approached, opening the way to a simultaneous acceleration of model improvement and parametric uncertainty quantification.

Non-linear loss of suitable wine regions over Europe in response to increasing global warming.

Evaluating the potential climatic suitability for premium wine production is crucial for adaptation planning in Europe. While new wine regions may emerge out of the traditional boundaries, most of the present-day renowned winemaking regions may be threatened by climate change. Here, we analyse the future evolution of the geography of wine production over Europe, through the definition of a novel climatic suitability indicator, which is calculated over the projected grapevine phenological phases to account for their possible contractions under global warming.

Early warning signal for a tipping point suggested by a millennial Atlantic Multidecadal Variability reconstruction.

Atlantic multidecadal variability is a coherent mode of natural climate variability occurring in the North Atlantic Ocean, with strong impacts on human societies and ecosystems worldwide. However, its periodicity and drivers are widely debated due to the short temporal extent of instrumental observations and competing effects of both internal and external climate factors acting on North Atlantic surface temperature variability. Here, we use a paleoclimate database and an advanced statistical framework to generate, evaluate, and compare 312 reconstructions of the Atlantic multidecadal variability over the past millennium, based on different indices and regression methods.

Increased risk of near term global warming due to a recent AMOC weakening.

Some of the new generation CMIP6 models are characterised by a strong temperature increase in response to increasing greenhouse gases concentration. At first glance, these models seem less consistent with the temperature warming observed over the last decades. Here, we investigate this issue through the prism of low-frequency internal variability by comparing with observations an ensemble of 32 historical simulations performed with the IPSL-CM6A-LR model, characterized by a rather large climate sensitivity.

On the risk of abrupt changes in the North Atlantic subpolar gyre in CMIP6 models.

CMIP5 models have been shown to exhibit rapid cooling events in their projections of the North Atlantic subpolar gyre. Here, we analyze the CMIP6 archive, searching for such rapid cooling events in the new generation of models. Four models out of 35 exhibit such instabilities.

Alleviation of an Arctic Sea Ice Bias in a Coupled Model Through Modifications in the Subgrid-Scale Orographic Parameterization.

In climate models, the subgrid-scale orography (SSO) parameterization imposes a blocked flow drag at low levels that is opposed to the local flow. In IPSL-CM6A-LR, an SSO lift force is also applied perpendicular to the local flow to account for the effect of locally blocked air in narrow valleys. Using IPSL-CM6A-LR sensitivity experiments, it is found that the tuning of both effects strongly impacts the atmospheric circulation.

North Atlantic climate far more predictable than models imply.

Quantifying signals and uncertainties in climate models is essential for the detection, attribution, prediction and projection of climate change. Although inter-model agreement is high for large-scale temperature signals, dynamical changes in atmospheric circulation are very uncertain. This leads to low confidence in regional projections, especially for precipitation, over the coming decades.

Ultrasmall Moment Incommensurate Spin Density Wave Order Masking a Ferromagnetic Quantum Critical Point in NbFe_{2}.

In the metallic magnet Nb_{1-y}Fe_{2+y}, the low temperature threshold of ferromagnetism can be investigated by varying the Fe excess y within a narrow homogeneity range. We use elastic neutron scattering to track the evolution of magnetic order from Fe-rich, ferromagnetic Nb_{0.981}Fe_{2.

Screened moments and extrinsic in-gap states in samarium hexaboride.

Samarium hexaboride (SmB) is a Kondo insulator, with a narrow gap due to hybridization between localized and conduction electrons. Despite being an insulator, many samples show metal-like properties. Rare-earth purification is exceedingly difficult, and nominally pure samples may contain 2% or more of impurities.

Author Correction: Tropical explosive volcanic eruptions can trigger El Niño by cooling tropical Africa.

The original version of this Article omitted a reference to previous work in 'Mann, M.E., Cane, M.

Publisher Correction: Tropical explosive volcanic eruptions can trigger El Niño by cooling tropical Africa.

A correction to this article has been published and is linked from the HTML version of this article.

Tropical explosive volcanic eruptions can trigger El Niño by cooling tropical Africa.

Stratospheric aerosols from large tropical explosive volcanic eruptions backscatter shortwave radiation and reduce the global mean surface temperature. Observations suggest that they also favour an El Niño within 2 years following the eruption. Modelling studies have, however, so far reached no consensus on either the sign or physical mechanism of El Niño response to volcanism.

Transcriptomic biomarkers of altered erythropoiesis to detect autologous blood transfusion.

Autologous blood transfusion is a powerful means of improving performance and remains one of the most challenging methods to detect. Recent investigations have identified 3 candidate reticulocytes genes whose expression was significantly influenced by blood transfusion. Using quantitative reverse transcription polymerase chain reaction as an alternative quantitative method, the present study supports that delta-aminolevulinate synthase 2 (ALAS2), carbonic anhydrase (CA1), and solute carrier family 4 member 1 (SLC4A1) genes are down-regulated post-transfusion.

Magnetic moments induce strong phonon renormalization in FeSi.

The interactions of electronic, spin and lattice degrees of freedom in solids result in complex phase diagrams, new emergent phenomena and technical applications. While electron-phonon coupling is well understood, and interactions between spin and electronic excitations are intensely investigated, only little is known about the dynamic interactions between spin and lattice excitations. Noncentrosymmetric FeSi is known to undergo with increasing temperature a crossover from insulating to metallic behaviour with concomitant magnetic fluctuations, and exhibits strongly temperature-dependent phonon energies.

Bidecadal North Atlantic ocean circulation variability controlled by timing of volcanic eruptions.

While bidecadal climate variability has been evidenced in several North Atlantic paleoclimate records, its drivers remain poorly understood. Here we show that the subset of CMIP5 historical climate simulations that produce such bidecadal variability exhibits a robust synchronization, with a maximum in Atlantic Meridional Overturning Circulation (AMOC) 15 years after the 1963 Agung eruption. The mechanisms at play involve salinity advection from the Arctic and explain the timing of Great Salinity Anomalies observed in the 1970s and the 1990s.

Interaction driven subgap spin exciton in the Kondo insulator SmB6.

Using inelastic neutron scattering, we map a 14 meV coherent resonant mode in the topological Kondo insulator SmB6 and describe its relation to the low energy insulating band structure. The resonant intensity is confined to the X and R high symmetry points, repeating outside the first Brillouin zone and dispersing less than 2 meV, with a 5d-like magnetic form factor. We present a slave-boson treatment of the Anderson Hamiltonian with a third neighbor dominated hybridized band structure.

Multiyear predictability of tropical marine productivity.

With the emergence of decadal predictability simulations, research toward forecasting variations of the climate system now covers a large range of timescales. However, assessment of the capacity to predict natural variations of relevant biogeochemical variables like carbon fluxes, pH, or marine primary productivity remains unexplored. Among these, the net primary productivity (NPP) is of particular relevance in a forecasting perspective.

Anisotropic spin dynamics in the Kondo semiconductor CeRu2Al10.

Spin dynamics in the new Kondo insulator compound CeRu2Al10 has been studied using unpolarized and polarized neutron scattering on single crystals. In the unconventional ordered phase forming below T0=27.3  K, two excitation branches are observed with significant intensities, the lower one of which has a gap of 4.

Comment on "Multiyear prediction of monthly mean Atlantic Meridional Overturning Circulation at 26.5°N".

Matei et al. (Reports, 6 January 2012, p. 76) claim to show skillful multiyear predictions of the Atlantic Meridional Overturning Circulation (AMOC).

Magnetic excitations in EuCu2(Si(x)Ge(1-x))2: from mixed valence towards magnetism.

We report the inelastic neutron scattering study of spin dynamics in EuCu(2)(Si(x)Ge(1-x))(2) (x = 1, 0.9, 0.75, 0.

Interplay of low-energy phonons and magnetic excitations in the Kondo insulator YbB12.

Peculiarities in the lattice dynamics of the Kondo insulator Y bB(12) have been studied by inelastic neutron scattering. Selected phonon modes were traced above and below the temperature region (T ~ 50 K) where the gap opens in the electron density of states. The intensities of some low-energy modes exhibit an anomalous temperature dependence for q vectors close to the Brillouin zone boundary, suggesting a renormalization of the phonon eigenvectors.

Polarized-neutron study of spin dynamics in the Kondo insulator YbB12.

Inelastic neutron scattering experiments have been performed on the archetype compound YbB(12), using neutron polarization analysis to separate the magnetic signal from the phonon background. With decreasing temperature, components characteristic for a single-site spin-fluctuation dynamics are suppressed, giving place to specific, strongly Q-dependent, low-energy excitations near the spin-gap edge. This crossover is discussed in terms of a simple crystal-field description of the incoherent high-temperature state and a predominantly local mechanism for the formation of the low-temperature singlet ground state.

Novel coexistence of superconductivity with two distinct magnetic orders.

The heavy fermion system exhibits properties that range from an incommensurate antiferromagnet for small to an exotic superconductor on the Ir-rich end of the phase diagram. At intermediate where antiferromagnetism coexists with superconductivity, two types of magnetic order are observed: the incommensurate one of and a new, commensurate antiferromagnetism that orders separately. The coexistence of -electron superconductivity with two distinct -electron magnetic orders is unique among unconventional superconductors, adding a new variety to the usual coexistence found in magnetic superconductors.

The rhizoplast of chrysomonads, a basal body-nucleus connector that polarises the dividing spindle.

An ultrastructure study of the rhizoplast in Synura petersenii, Mallomonas fastigiata, and M. insignis shows that it consists of 15-20 striated rootlets that form a claw or an incomplete cone over the nucleus. These rootlets course along one face of the nucleus between the nuclear membrane and the cis-face of the Golgi stack of cisternae.