Publications by authors named "Mignon T Van den Elzen"
Background: Chronic spontaneous urticaria (CSU) is characterized by recurrent itchy weals and/or angioedema and is believed to be driven by mast cell activation. It was shown that excessive mast cell activation during anaphylaxis initiates contact activation, resulting in bradykinin release. Evidence for bradykinin release was never demonstrated in CSU.
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- Treatment with second-generation antihistamines is effective for chronic spontaneous urticaria (CSU) patients, but many require higher doses for better results, with 78% experiencing up-dosing and 23% responding favorably.
- A majority of patients (80%) with wheals or wheals and angioedema needed higher doses, and those who didn't respond to fourfold doses had some success with even higher dosages.
- Side effects were reported by 20% of patients with a minimal increase for those on extremely high doses, suggesting that higher dosages may be a viable treatment option to reduce reliance on more complex therapies.
Background: Recombinant human C1 inhibitor (rhC1INH) for on-demand treatment of hereditary angioedema is purified from milk of transgenic rabbits. It contains low amounts (<0.002%) of host-related impurities, which could trigger hypersensitivity reactions in patients with rabbit allergy (RA) and/or cow's milk allergy (CMA).
View Article and Find Full Text PDFBackground: Non-hereditary angioedema (non-HAE) is characterized by local swelling due to self-limiting, subcutaneous or submucosal extravasation of fluid, and can be divided into three subtypes. These subtypes are believed to have different pathophysiological backgrounds and are referred to in recent guidelines as bradykinin-mediated (e.g.
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