Identification of AKNA Gene and Its Role for Genetic Susceptibility in Epithelial Ovarian Cancer.

AKNA is identified as a gene that regulates inflammation, immune response, and Epithelial-Mesenchymal Transition (EMT), which plays an important role in the progression of epithelial ovarian cancer. In this study, we analyzed the genotype and allele distribution as well as 3D modeling of one of the AKNA rs10817595 (-1372 C>A). The distribution of genotypes and alleles was analyzed using the T-ARMS PCR method on 63 ovarian cancer samples and 65 controls.