Publications by authors named "Mieu M T Brooks"
Article Synopsis
- Parkinson's disease and similar disorders involve chronic neuroinflammation, which has led to the exploration of anti-inflammatory treatments to potentially alleviate symptoms.
- In a study using mice expressing a mutation associated with PD, the introduction of the anti-inflammatory cytokine Il-10 unexpectedly resulted in increased neuroinflammation and early mortality instead of improvement.
- Further investigation revealed that a variant of Il-10, with mainly immunosuppressive effects (vIl-10), also led to worsened outcomes, suggesting that manipulating immune responses can have complicated and sometimes harmful effects in neurodegenerative diseases.
Background: Prionoid transmission of α-synuclein (αSyn) aggregates along neuroanatomically connected projections is posited to underlie disease progression in α-synucleinopathies. Here, we specifically wanted to study whether this prionoid progression occurs via direct inter-neuronal transfer and, if so, would intrastriatal injection of αSyn aggregates lead to nigral degeneration.
Methods: To test prionoid transmission of αSyn aggregates along the nigro-striatal pathway, we injected amyloidogenic αSyn aggregates into two different regions of the striatum of adult human wild type αSyn transgenic mice (Line M20) or non-transgenic (NTG) mice and aged for 4 months.
Background: Cell-to-cell transmission of α-synuclein (αSyn) is hypothesized to play an important role in disease progression in synucleinopathies. This process involves cellular uptake of extracellular amyloidogenic αSyn seeds followed by seeding of endogenous αSyn. Though it is well known that αSyn is an immunogenic protein that can interact with immune receptors, the role of innate immunity in regulating induction of αSyn pathology in vivo is unknown.
View Article and Find Full Text PDF