Multimodal Evoked Potentials as Potential Biomarkers of Disease Activity in Patients With Clinically Isolated Syndrome.

Objective: There is an ongoing search for markers useful in monitoring and predicting disease activity at the early stage of multiple sclerosis (MS). The goals of this study were to prospectively evaluate the changes in parameters of multimodal evoked potentials (EP) and cognition within a 3-year follow-up period in patients with clinically isolated syndrome (CIS), and to assess the prognostic value of baseline findings with regard to the disease outcomes.

Methods: In 29 patients (20 women, nine men, mean age 31.

Multiple fusiform cerebral aneurysms detected after atrial myxoma resection: a report of two cases.

N/A.

Cognitive performance, fatigue and event-related potentials in patients with clinically isolated syndrome.

Objectives: Cognitive impairment and fatigue are regarded as important aspects of multiple sclerosis. The aim of this study was to evaluate cognitive performance, the level of fatigue and parameters of event-related potentials (ERP) in patients diagnosed with clinically isolated syndrome (CIS).

Patients And Methods: The study comprised 44 patients with CIS and 45 healthy controls.

Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue.

The aim of this study was to evaluate event-related potentials (ERP) and cognition in multiple sclerosis (MS) patients with regard to fatigue and disease-related variables. The study comprised 86 MS patients and 40 controls. Fatigue was assessed using the Fatigue Severity Scale (FSS/FSS-5) and the Modified Fatigue Impact Scale (MFIS/MFISmod).

Acute hyperkinetic syndrome due to ephedrone abuse.

Objectives: A new form of manganese poisoning is related to the intravenous use of self-prepared methcathinone hydrochloride (ephedrone). Manganese encephalopathy typically manifests as a levodopa-resistant parkinsonism.

Main Points: A 32-year-old drug-addicted man with acute gait disturbances after the ephedrone injections was presented.

Magnetic resonance spectroscopy findings as related to fatigue and cognitive performance in multiple sclerosis patients with mild disability.

Background: The origin of fatigue in multiple sclerosis (MS) remains unclear. Magnetic resonance spectroscopy (MRS) provides an insight into metabolic properties of the brain.

Objectives: The aim of the study was to evaluate brain MRS measurements in MS patients, with regard to fatigue and cognition.

[Acute idiopathic longitudinally extensive transverse myelitis with peripheral axonal motor neuropathy].

Acute longitudinally extensive transverse myelitis (LETM) is a rare disease of autoimmune, connective tissue or infectious etiology (bacterial or viral) in which spinal cord lesion extends vertically over three or more vertebral segments. The most common cause of LETM is neuromyelitis optica (Devic's syndrome). It's typically clinically characterized by a tetraparesis or paraparesis of the lower extremities, superficial and deep sensation disturbances and sphincter dysfunction.

[Ballism as a rare form of hyperkinetic movement disorder].

Hemiballism is a very rare movement disorderthat presents with involuntary unilateral flinging movements of the limbs. The movements are often violent and have wide amplitudes of motion. Hemichorea and hemiballism share pathophysiology and etiology, and commonly coexist in the same patient.

Neuropsychological testing and event-related potentials in the assessment of cognitive performance in the patients with multiple sclerosis--a pilot study.

Aims: The aim of the study was to evaluate cognitive impairment in multiple sclerosis (MS) patients using neuropsychological testing (NT) and auditory event-related potentials (ERPs) with reference to clinical variables, with an attempt to re-assess NT and ERP results after a year.

Methods: The study comprised 21 patients with MS. ERPs results were compared to age-matched controls.

Mild cognitive impairment and event-related potentials in patients with cerebral atrophy and leukoaraiosis.

Objective: The influence of cerebral atrophy and leukoaraiosis (LA) on the degree and profile of cognitive impairment remains unclear.

Design: The aim of the study was to assess neuropsychological features of cognitive performance and parameters of event-related potentials (ERP) in subjects with generalised cerebral atrophy and LA.

Setting: Department of Neurology, University of Medicine.

[Epilepsy in the elderly people].

Recently an increasing number of cases of epilepsy revealed after 60 years of age have been noted. Epilepsy in the elderly may cause some diagnostic and therapeutic difficulties, it constitutes social problems as well. The authors present current epidemiological data, discuss pathogenesis of seizures, clinical course and prognosis, rules of differential diagnosis and treatment, highlighting specific features of the disease in this age group.

[Tau-pathies: neurodegenerative diseases with pathology involving tau protein].

Microtubule-associated protein tau (MAP-tau) plays an important role in stabilizing neuronal structure, in axonal transport, regulating cellular division, and apoptotic processes. In recent years the structure and functions of MAP-tau, as well as its physiological changes and pathology, have been extensively studied. Degenerative diseases of the central nervous system having MAP-tau involved in their pathogenesis are called tau-pathies.

Epilepsy in middle-aged and elderly people: a three-year observation.

An analysis of the medical documentation and investigation of 130 cases of epilepsy diagnosed in a group of people over 50 years of age (average: 65.4 years) revealed that the most common type of seizure in the group studied was partial (66.2%), followed by seizures with secondary generalization (33.