Comprehensive Analysis of the ATP-binding Cassette Subfamily B Across Renal Cancers Identifies ABCB8 Overexpression in Phenotypically Aggressive Clear Cell Renal Cell Carcinoma.

Background: ATP-binding cassette (ABC) transporters play a crucial role in the development of multidrug resistance in diverse cancer entities.

Objective: Our study was designed to comprehensively analyze the ABC subfamily B (ABCB) in renal cell carcinoma (RCC) using The Cancer Genome Atlas (TCGA) datasets.

Design, Setting, And Participants: We performed systematic survival analyses of ABCB1-10 using the TCGA datasets for clear cell, papillary, and chromophobe RCC.

The long non-coding RNA lnc-ZNF180-2 is a prognostic biomarker in patients with clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) is among the most common human malignancies. Long non-coding RNAs (lncRNA) regulate various cellular functions and have been implicated in ccRCC pathogenesis. In order to decipher the molecular biology of this tumor and to identify potential prognostic biomarkers and therapeutic targets, we re-evaluated published lncRNA expression profiling data.

Histone methylation defines an epigenetic entity in penile squamous cell carcinoma.

Purpose: Earlier studies indicate that epigenetics contribute to the pathogenesis of penile squamous cell carcinoma. Histone methylation patterns are frequently altered during carcinogenesis. Therefore, we investigated the methylation pattern of the histones H3K4, H3K9 and H3K27 in penile carcinoma and normal tissue.

The influence of suspension hypokinesia on contractile properties of slow and fast twitch muscles of young growing and adult rats.

The influence of the lack of the gravity force on contractile properties of the slow-twitch soleus (SOL) and the fast-twitch extensor digitorum longus (EDL) muscles was investigated in 3 week or 6-month-old rats suspended by their tail. In both groups suspension hypokinesia (SH) lasting 3 weeks or longer leads to a marked decrease of the mass and of the mean cross-sectional area of the SOL. The SOL of suspended animals shows decreased contraction and half-relaxation times and a lower tension of the single twitch, a decreased maximum tetanic force output, an increased fusion frequency and a decreased tetanus-half-rise time.

[Effectiveness of combined plasma exchange treatment in fulminant viral hepatitis].

The plasma exchange is an effective measure in the treatment of acute liver failure. The authors report their own first experiences in this field in the management of fulminant viral hepatitis. Four out of 7 treated patients survived.