Publications by authors named "Miere A"
Macular telangiectasia type 2 in a patient with Down syndrome: A possible association.
Am J Ophthalmol Case Rep
December 2024
Purpose: Down syndrome (DS) is one of the most prevalent genetic diseases associated with a variety of ophthalmic disorders, including reported retinal abnormalities. Macular telangiectasia type 2 (MacTel 2) is a late-onset neurodegenerative retinal disease with a substantial genetic component. We hereby describe a case of a female with DS who presented with MacTel 2, and we discuss the possible pathways associating both entities.
View Article and Find Full Text PDFPurpose: To assess the sensitivity and specificity of the "triple layer sign" (TLS) (retinal pigment epithelium (RPE), neovascular tissue, and Bruch's membrane) on structural optical coherence tomography (OCT) images for the diagnosis of treatment-naïve non-exudative type-1 macular neovascularization (NE-MNV) in age-related macular degeneration (AMD).
Design: Cross-sectional study.
Methods: Two masked retinal experts evaluated the presence of the TLS in eyes with NE-MNV and controls with an RPE elevation without exudation due to other causes than NE-MNV in AMD [e.
Navigated Focal Laser of Macular Telangiectasia Type I (Adult-Onset Coats' Disease).
Ophthalmic Surg Lasers Imaging Retina
September 2024
We aimed to evaluate the anatomical and functional outcome of selective photocoagulation of idiopathic macular telangiectasia type 1 by navigated focal laser (Navilas, OD-OS GmBH). Consecutive patients with idiopathic macular telangiectasia type 1 were included in the analysis. All patients were treated with navigated focal laser, planned on multimodal imaging.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to develop a deep learning model to automatically predict late recurrence of rhegmatogenous retinal detachment using ultra-wide field images.
- Researchers analyzed data from patients over 18 who underwent surgery for retinal detachment, training four different models on preoperative and postoperative images.
- The models achieved high accuracy rates (up to 91.1%) in predicting recurrence, highlighting potential risk factors like extensive laser retinopexy and asymmetrical staphyloma.
Objective: To assess the effectiveness and safety of a rigorous short-term supine position in preventing inadvertent retinal displacement after pars plana vitrectomy (PPV) with gas tamponade for rhegmatogenous retinal detachment (RRD).
Methods: We conducted a retrospective observational analysis of a case series at two ophthalmological surgical centers. We included eyes diagnosed with macula-off RRD that maintained a strict face-up position for three hours immediately after PPV with intraoperative perfluorocarbon liquid (PFCL) and 20% sulfur hexafluoride (SF6) tamponade.
Purpose: To report three cases of hemorrhagic unilateral retinopathy, diagnosed by multimodal imaging.
Methods: Case report of 3 patients, 2 women and one man, aged 51, 74, and 52, respectively.
Results: Symptoms were acute floaters, blurred vision, or central scotoma, unilateral in all cases.
Purpose: To compare photoreceptor density automated quantification in eyes with subretinal drusenoid deposits (SDD) and healthy controls using Heidelberg Spectralis High Magnification Module (HMM) imaging.
Methods: Twelve eyes of 6 patients with intermediate AMD, presenting with SDD were included, as well as twelve eyes of healthy controls. Individual dot SDD within the central 30° retina were examined with infrared confocal laser ophthalmoscopy, HMM, and spectral-domain optical coherence tomography (SD-OCT).
Retro-mode imaging for the diagnosis of optic disc drusen: a case series.
Arch Soc Esp Oftalmol (Engl Ed)
May 2024
Objective: We aimed to compare the detectability of optic disc drusen (ODD), using various non-invasive imaging techniques, including the novel retro-mode imaging (RMI), as well as to analyze the morphological characteristics of ODD on RMI.
Methods: This study involved seven patients with bilateral ODD, totaling 14 eyes. Multimodal imaging techniques, including multicolor fundus photography (MC), near-infrared reflectance (NIR), green and blue light fundus autofluorescence (G-FAF and B-FAF, respectively), and RMI were used to examine the eyes.
Background/purpose: Evaluate the performance of a deep learning algorithm for the automated detection and grading of vitritis on ultrawide-field imaging.
Methods: Cross-sectional noninterventional study. Ultrawide-field fundus retinophotographs of uveitis patients were used.
Article Synopsis
- The study aimed to analyze the challenges in diagnosing a 56-year-old woman with early symptoms of late-onset retinal degeneration (L-ORD) over an eleven-year follow-up period, stressing the importance of electrophysiological tests for detecting inherited retinal diseases.
- Initially, she was misdiagnosed with fundus albipunctatus, but after a decade, tests showed deterioration in rod and cone responses, prompting further genetic testing.
- Ultimately, genetic results confirmed the diagnosis of L-ORD linked to a variation in the C1QTNF5 gene, highlighting the need for careful monitoring and diagnostic follow-ups in such cases.
Article Synopsis
- - An AI-based deep learning classifier was developed to help doctors differentiate between age-related geographic atrophy and extensive macular atrophy with pseudodrusen-like appearance using fundus autofluorescence (FAF) images.
- - The study involved 300 patients, with the classifiers trained on high-quality FAF images and evaluated on a separate set; the 30° FAF classifier had a sensitivity of 84.6% and specificity of 85.3%, while the 55° FAF classifier performed even better with 90% sensitivity and 84.6% specificity.
- - Results indicate that artificial intelligence can effectively distinguish between atrophy linked to AMD and EMAP, with better performance observed using wider field FAF images.
The Impact of Diabetic Retinopathy on the Choriocapillaris in Neovascular AMD.
Invest Ophthalmol Vis Sci
November 2023
Purpose: To investigate the impact of diabetic retinopathy (DR) on morphological choriocapillaris (CC) modifications in eyes with type 1 macular neovascularization (MNV) secondary to AMD using optical coherence tomography angiography (OCTA).
Methods: Eyes with AMD-related type 1 MNV with and without DR were prospectively included. We performed 3 × 3 mm OCTA scans at two visits: before the loading phase of intravitreal injections of aflibercept (T1) and 1 month after the last injection (T2).
Article Synopsis
- * A series of visual tests and imaging techniques were conducted to examine the patients' eye conditions, confirming the presence of NARP syndrome symptoms in all three individuals.
- * The findings highlight the variable progression of NARP syndrome and emphasize the need for a comprehensive approach that includes both neurological and eye evaluations for effective disease management.
Article Synopsis
- The study investigates how hemodialysis (HD) affects the retinal and choroidal blood vessels in patients with end-stage kidney disease (ESKD) using advanced imaging techniques.
- Results showed a significant decrease in subfoveal choroidal thickness (SCT) and an increase in non-perfusion of the choriocapillaris after HD, while retinal vascular density remained unchanged.
- A higher level of B-Nitric Peptide (BNP) before HD was correlated with a greater decrease in SCT, suggesting a link between this biomarker and choroidal health in ESKD patients undergoing dialysis.
Purpose: To the describe OCT imaging characteristics of a cohort of patients showing spontaneously closing degenerative or mixed type lamellar macular holes (LMH) and to compare them to the ones of a sex and age matched group showing stable lesions.
Methods: Patients diagnosed with degenerative and mixed type LMHs showing OCT-documented spontaneous anatomical closure were retrospectively selected from 3 specialized retina centres. An equal number of age and sex matching subjects were randomly selected among patients with anatomically stable lesions.
Purpose: To describe multimodal imaging of two cases of bilateral non-vascularized pigment epithelial detachments (PED) in young patients with a long-term follow-up.
Methods: A complete ophthalmological examination was performed at each follow-up visit including best corrected visual acuity (BCVA), intraocular pressure, slit lamp examination, spectral domain optical coherence tomography (SD-OCT), fluorescein and indocyanine green angiography, OCT angiography.
Results: Multimodal imaging of two women presenting avascular PED, aged 43 and 57, respectively, was described.
Purpose: To analyze differences in refractive outcome Δ (difference between postoperative and expected refractive error) and in anterior segment changes between cataract surgery patients and combined phacovitrectomy patients. We also aimed to provide a corrective formula allowing to minimise the refractive outcome Δ in combined surgery patients.
Methods: Candidates for phacoemulsification and combined phacovitrectomy (respectively PHACO and COMBINED groups) were prospectively enrolled in two specialised centres.
Widefield oct-angiography-based classification of sickle cell retinopathy.
Graefes Arch Clin Exp Ophthalmol
October 2023
Purpose: To assess the capillary non-perfusion in different concentric sectors on widefield optical coherence tomography angiography (WF-OCTA) and to correlate the ratio of non-perfusion (RNP) to the severity of sickle cell retinopathy (SCR).
Methods: This retrospective, cross-sectional study included eyes of patients with various sickle cell disease (SCD) genotypes having undergone WF-OCTA and ultra-widefield color fundus photography (UWF-CFP). Eyes were grouped as no SCR, non-proliferative SCR or proliferative SCR.
Purpose: Geometric perfusion deficit (GPD) is a newly described OCT angiography (OCTA) parameter identifying the total area of presumed retinal ischemia. The aim of our study is to characterize differences in GPD and other common quantitative OCTA parameters between macular full field, perivenular zones, and periarteriolar zones for each clinical stage of nonproliferative diabetic retinopathy (DR) and to assess the influence of ultrahigh-speed acquisition and averaging on the described differences.
Design: Prospective observational study.
Objectives: To investigate the correlation between the AI-measured area of the lacquer cracks (LC) at their first detection and the occurrence of a choroidal neovascularization (CNV) during the follow-up in patients affected by pathologic myopia. Secondary outcome was the detection of a correlation between the time to onset of CNV with both baseline LC area and LC area increase during follow-up.
Methods: Optical coherence tomography (OCT) acquisitions of patients diagnosed with LC were retrospectively analysed.