Periocular Adverse Reactions to Omidenepag Isopropyl.

Purpose: To investigate the periocular adverse reactions to omidenepag isopropyl (OMDI).

Design: Nonrandomized comparative clinical study.

Methods: We enrolled 100 patients (100 eyes) with primary open-angle glaucoma or ocular hypertension who received initial treatment with OMDI or tafluprost in only 1 eye for ≥6 months.

Built-in LED contact lens electrode for S-cone electroretinographic recordings.

Purpose: To characterize the cone electroretinograms (ERGs) elicited by chromatic stimuli obtained from a newly-developed contact lens electrode with built-in light-emitting diodes (LEDs) emitting different colors.

Methods: Cone ERGs were recorded from normal subjects with a contact lens electrode with built-in blue (430 nm), red (644 nm), and white LEDs. These LEDs have a wide range of luminance intensities (3 log units), and can be used as either the background illumination or the stimulus in any combination.

S-cone electroretinograms in multiple evanescent white dot syndrome.

Cone electroretinograms (ERGs), elicited by different color flashes under Ganzfeld conditions, were recorded from 6 patients with multiple evanescent white dot syndrome (MEWDS). All of the patients had normal color vision as determined by the Farnsworth Panel D-15 except for one who showed non-specific errors. The b-waves elicited from short wavelength sensitive (S-) cones were reduced more than the mixed long (L-) and middle (M-) wavelength sensitive cones in the affected eyes.

Selective reduction of S-cone response and on-response in the cone electroretinograms of patients with X-linked retinoschisis.

Purpose: To examine the electroretinograms (ERGs) of the short-wavelength-sensitive (S-) and the mixed long- and middle-wavelength-sensitive (L,M-) cones, and the ON- and OFF-responses of the cone ERGs in three patients with X-linked juvenile retinoschisis (XLRS).

Methods: Cone ERGs elicited by different color flashes and those elicited by long duration stimuli under Ganzfeld conditions were recorded from three patients with XLRS.

Results: The S-cone b-waves were undetectable to short-wavelength stimuli in all three XLRS patients, while the L,M-cone ERG b-waves were within the normal range.