Polymeric ligands as homogeneous, reusable catalyst systems for copper assisted click chemistry.

Tris-(benzyltriazolylmethyl)amine (TBTA) has been immobilized onto a styrenic monomer and subsequently copolymerized with styrene to afford catalytically active and reusable copolymers for the CuAAC reaction.

Star-Shaped Polyacrylates: Highly Functionalized Architectures via CuAAC Click Conjugation.

Well-defined functional star-shaped polymer structures with up to 29 arms have been successfully synthesized by the combination of atom transfer radical polymerization (ATRP) and click chemistry. First, azide end-functionalized poly(isobornyl acrylate) (PiBA) star-shaped polymers were prepared by successive ATRP and bromine substitution. Subsequently, alkyne end-functionalized molecules and polymers were introduced onto the star-shaped PiBA bearing pendant azide moieties by copper-catalyzed azide-alkyne cycloaddition (CuAAC).

Design and use of organic nanoparticles prepared from star-shaped polymers with reactive end groups.

Star-shaped poly(isobornyl acrylate) (PiBA) was prepared by atom transfer radical polymerization (ATRP) using multifunctional initiators. The optimal ATRP conditions were determined to minimize star-star coupling and to preserve high end group functionality (>90%). Star-shaped PiBA with a narrow polydispersity index was synthesized with 4, 6, and 12 arms and of varying molecular weight (10,000 to 100,000 g x mol(-1)) using 4 equiv of a Cu(I)Br/PMDETA catalyst system in acetone.