Publications by authors named "Mieke H Verfaellie"
Article Synopsis
- The study explores the biological differences linked to PTSD by examining DNA methylation changes in blood, suggesting they could indicate susceptibility or effects of trauma.
- Conducted by the Psychiatric Genomics Consortium, the research included nearly 5,100 participants to identify specific genetic markers associated with PTSD.
- Results showed 11 significant CpG sites related to PTSD, with some also showing correlations between blood and brain tissue methylation, highlighting their potential role in understanding PTSD biology.
Article Synopsis
- Researchers aimed to create and validate Methylation Risk Scores (MRS) using machine learning to identify individuals at risk for PTSD based on genomic and trauma exposure data.
- The study developed three models: eMRS (which combines trauma exposure and methylation data), MoRS (which relies only on methylation data), and MoRSAE (which adjusts MoRS for trauma exposure).
- The eMRS model showed the best performance with a 92% accuracy, and all models were able to predict post-deployment PTSD significantly, suggesting that including trauma exposure improves risk assessment.
Article Synopsis
- The study investigates the link between post-traumatic stress disorder (PTSD) and differences in DNA methylation, a type of gene regulation, in blood samples from individuals diagnosed with PTSD compared to trauma-exposed controls.
- Researchers conducted a large-scale analysis involving over 5,000 participants from various civilian and military studies, using standardized procedures for PTSD assessment and DNA methylation testing.
- The results revealed 11 specific DNA methylation sites associated with PTSD, and found similarities in methylation patterns between blood and brain tissues, suggesting a biological basis for the condition.
Objective: Verbal instructions comprise an important element of clinical practice, however, their effectiveness in promoting movement organization in persons with cerebrovascular accident (CVA) has not been well investigated.
Method: A counterbalanced, repeated-measures design was used to examine the effects of externally focused (task-related) versus internally focused (movement-related) instructions on movement kinematics during three functional reaching tasks. Participants included 16 persons with stroke who were able to perform the tasks with their affected arm and 17 age-matched adults without neurological impairments.