Immunohistochemical detection of mutant p53-suppressor gene product in patients with breast cancer: influence on metastasis-free survival.

Overexpression of p53-protein appears to be a common event in primary breast cancer. It has been proposed that the presence of elevated levels of this protein may be an independent prognostic factor and may be important for the ability of a tumor to metastasize. This study was performed to evaluate the influence of immunohistochemically detectable mutant p53-protein on metastasis-free survival of patients with breast cancer.

Malignant transformation of mucinous ovarian cystadenomas of intestinal epithelial type.

We studied 116 benign and 18 borderline malignant mucinous ovarian cystadenomas. Their epithelial lining was compared with normal epithelium of the uterine cervix and that of the small and large intestines, by both light and electron microscopy as well as histochemically. This morphological and histochemical analysis enabled us to subdivide mucinous cystadenomas into cervical, mixed and intestinal epithelial types.

Morphology of intrarenal arteries in transplants and in diseased kidneys of patients treated by long-term dialysis.

Intimal fibrosis of intrarenal arteries is rarely found in diseased kidneys of patients not treated by dialysis, but it is common and intensive in cases subjected to this therapy as well as in renal transplants. In this paper the incidence rate and morphology of this lesion are presented in 10 renal grafts and 13 kidneys of patients treated by chronic dialyses. The factors influencing the appearance of intimal fibrosis are discussed.