Publications by authors named "Midori Yukino-Iwashita"
Article Synopsis
- Research shows that women with supra-normal left ventricular ejection fraction (snEF) have a higher risk of adverse heart failure outcomes compared to men, particularly in the mildly reduced EF (HFmrEF) category.
- A study involving nearly 4,000 heart failure patients found that women were less likely to receive guideline-directed medical therapy (GDMT) compared to men, which could impact their health outcomes.
- The findings suggest a U-shaped relationship between left ventricular ejection fraction (LVEF) and long-term health risks, indicating the need for sex-specific treatment guidelines to improve heart failure management for women.
Biological sex is one of the major factors characterizing the heart failure (HF) patient phenotype. Understanding sex-related differences in HF is crucial to implement personalized care for HF patients with various phenotypes. There are sex differences in left ventricular (LV) remodeling patterns in the HF setting, namely, more likely concentric remodeling and diastolic dysfunction in women and eccentric remodeling and systolic dysfunction in men.
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- Sodium-glucose cotransporter-2 inhibitors (SGLT-2is) benefit cardiovascular health, reducing adverse events in both diabetic and heart failure (HF) patients.
- Recent guidelines endorse SGLT-2is for HF patients, but concerns about weight loss and adverse effects, particularly in those with frailty or sarcopenia, persist.
- There's no clear consensus on the best methods to assess frailty or the appropriate criteria for safely prescribing SGLT-2is to HF patients, prompting a review of assessment techniques and treatment efficacy.
A wide range of anti-myocardial autoantibodies have been reported since the 1970s. Among them, autoantibodies against the β-adrenergic receptor (βAR-AAb) have been the most thoroughly investigated, especially in dilated cardiomyopathy (DCM). ΒAR-Aabs have agonist effects inducing desensitization of βAR, cardiomyocyte apoptosis, and sustained calcium influx which lead to cardiac dysfunction and arrhythmias.
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- Venous thromboembolism (VTE), often called cancer-associated thrombosis (CAT), is a common issue among cancer patients, yet its clinical features are not well-studied.
- A study analyzed 259 patients treated for pulmonary embolism (PE), finding that those with cancer were more often diagnosed incidentally and had lower severity of PE but experienced a worse prognosis.
- Higher D-dimer levels at discharge were linked to poor outcomes, indicating that cancer patients might face a heightened risk of major cardiovascular events and mortality despite the less severe initial PE.
Article Synopsis
- * Short-chain fatty acids (SCFAs), which come from gut microbiota, may be linked to heart failure and other cardiovascular diseases due to their concentration changes in the body.
- * SCFAs could help in managing HF through various mechanisms, such as influencing receptors, reducing inflammation, and supporting heart energy needs, but these processes require more research to fully understand.