Contact-Killing Antibacterial Polystyrene Polymerized Using a Quaternized Cationic Initiator.

Contact-killing antibacterial materials are attracting attention owing to their ability for sustained antibacterial activity. However, contact-killing antibacterial polystyrene (PS) has not been extensively studied because its chemically stable structure impedes chemical modification. In this study, we developed an antibacterial PS sheet with a contact-killing surface using PS synthesized from 2,2'-azobis-[2-(1,3-dimethyl-4,5-dihydro-1-imidazol-3-ium-2-yl)]propane triflate (ADIP) as a radical initiator with cationic moieties.

Impact of Physical Inactivity on the Risk of Disability and Hospitalization in Older Patients with Advanced Lung Cancer.

Purpose: This prospective observational study aimed to explore the influence of physical inactivity during initial chemotherapy on the risk of disability and hospitalization in later life among older patients with advanced non-small-cell lung cancer (NSCLC).

Patients And Methods: Patients aged 70 or above who were scheduled to receive first-line chemotherapy for newly diagnosed advanced NSCLC were recruited for the study. An electronic pedometer was used to measure daily steps; based on the change rate (cutoff: -12.

Thermo-Responsive Nanocomposite Hydrogels Based on PEG--PLGA Diblock Copolymer and Laponite.

Poly(ethylene glycol)--poly(d,l-lactide--glycolide) (PEG--PLGA) diblock copolymers are widely known as polymeric surfactants for biomedical applications, and exhibit high solubility in water compared to PLGA--PEG--PLGA triblock copolymers known as gelation agents. In order to overcome the difficulties in the preparation of thermo-responsive hydrogels based on PLGA--PEG--PLGA due to the low solubility in water, the fabrication of thermo-responsive hydrogels based on PEG--PLGA with high solubility in water was attempted by adding laponite to the PEG--PLGA solution. In detail, PEG--PLGA with high solubility in water (i.