Publications by authors named "Midhun George Thomas"
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Synopsis of recent research by authors named "Midhun George Thomas"
- Midhun George Thomas focuses on the catalytic mechanisms and dynamics of non-heme Fe(II)/2-oxoglutarate-dependent histone demethylases, utilizing advanced molecular dynamics and combined quantum mechanics/molecular mechanics methodologies to uncover the nuances of enzyme catalysis.
- His recent studies analyze specific histone demethylases, including KDM4A and KDM2A, exploring how variations in substrate methylation and second coordination sphere factors can impact catalytic efficiency and selectivity, which has implications for epigenetic regulation and cancer biology.
- Thomas's research also reveals the importance of protein environments in regulating dioxygen binding and coordination in oxygenases, illustrating distinct mechanisms among different enzymes and contributing to insights on enzyme redesign for therapeutic applications.
