Publications by authors named "Middleton R"

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

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Background: Burnout is among the greatest challenges facing healthcare today. Healthcare providers have been found to experience burnout at significant rates, with COVID-19 exacerbating the challenge. Burnout in the healthcare setting has been associated with decreases in job satisfaction, productivity, professionalism, quality of care, and patient satisfaction, as well as increases in career choice regret, intent to leave, and patient safety incidents.

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Purpose: Both local tumor control and distant metastasis are important indicators of the efficacy of radiation therapy treatment. Synchrotron microbeam radiation therapy (MRT), spatially fractionated radiation delivered at ultrahigh dose rates, shows remarkable normal tissue sparing with excellent local control in some models. Some MRT regimens trigger an antitumor immune response that contributes not only to the local but also to systemic treatment efficacy.

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Aim: To explore how postgraduate leadership education is translated into practice and how leadership practices and behaviours are sustained following completion of a leadership program.

Design: A qualitative exploratory study using an appreciative inquiry approach.

Methods: A single Health District, partnered with a regional university, offering a 12-month leadership program, the Effective Leadership in Health Program.

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Article Synopsis
  • The paper aims to explore the challenges rural nurses face during resuscitations, highlighting how this contributes to their professional isolation, and to propose strategies to alleviate these issues.
  • It emphasizes that professional isolation is prevalent in low-resourced rural healthcare settings, particularly where small emergency departments are located far from major hospitals, and notes a lack of research on effective interventions.
  • The findings suggest that professional isolation hinders skill development and career intent among rural nurses, and recommends solutions like leadership training, mentorship, and debriefing sessions to help improve their professional experiences and connections.
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Introduction: Various techniques have been described for restoring leg length and offset during total hip arthroplasty (THA). We herein describe a novel "Quartered Head Technique" (QHT) involving a series of femoral osteotomies.

Methods: 124 hips were included in the analysis.

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Background: The COVID-19 pandemic significantly reduced hip and knee arthroplasty surgeries across the English NHS. With the resumption of regular operations postpandemic, efforts have been made to address the surgical backlog by maximising capacity. This study assesses the current activity rates of hip and knee arthroplasty in the NHS and their return to prepandemic levels.

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Healthcare systems are facing unprecedented need to respond to an ever-evolving context of providing safe person-centred care to its citizens and staff. This transformation requires a rethink of healthcare leadership. Systems leaders are critical for culture change; to support safe patient care, facilitate innovation, build person-centred teams, and develop a collaborative workforce.

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A search for the exclusive hadronic decays W^{±}→π^{±}γ, W^{±}→K^{±}γ, and W^{±}→ρ^{±}γ is performed using up to 140  fb^{-1} of proton-proton collisions recorded with the ATLAS detector at a center-of-mass energy of sqrt[s]=13  TeV. If observed, these rare processes would provide a unique test bench for the quantum chromodynamics factorization formalism used to calculate cross sections at colliders. Additionally, at future colliders, these decays could offer a new way to measure the W boson mass through fully reconstructed decay products.

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Article Synopsis
  • - The ATLAS experiment at the LHC conducted a search for long-lived particles (LLPs) using a large dataset (140 fb^{-1}) from proton-proton collisions at 13 TeV, focusing on LLPs with masses from 5 to 55 GeV that decay within the inner detector.
  • - The study considered scenarios where LLPs are produced from exotic Higgs boson decays and models involving axionlike particles (ALPs).
  • - No significant findings above expected background levels were detected, leading to the establishment of upper limits on various production rates involving the Higgs boson and the top quark related to LLPs and ALPs.
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  • The study investigates the associated production of Higgs and W bosons, focusing on how the relative signs of the Higgs couplings to W and Z bosons impact the process.
  • Two specific searches were conducted using large amounts of collision data from the LHC to analyze different coupling scenarios: one for opposite-sign couplings and another for same-sign (standard model-like) couplings.
  • The results significantly exclude the opposite-sign coupling hypothesis and set a strict upper limit on the production rate of this process compared to standard model predictions.
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Background: There is growing interest in the use of nutrition and dietary supplements to optimize training and time-trial (TT) performance in cyclists. Separately, quercetin (QCT) and citrulline (CIT) have been used as ergogenic aids to improve oxygen (VO) kinetics, perceived effort, and cycling TT performance. However, whether the combination of QCT and CIT can provide additive benefits and further enhance cycling performance production is currently unknown.

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Predicting aging trajectories through biomarkers of biological aging can guide interventions that optimize healthy lifespan in humans and companion animals. Differences in physiology, genetics, nutrition, and lifestyle limit the generalization of such biomarkers and may therefore require species-specific algorithms. Here, we compared correlations of standard clinical blood parameters with survival probability in humans with those of the two most common mammalian companion animals, cats and dogs, and highlighted universal and species-specific relationships.

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Aims: To identify facilitators and barriers and tailor implementation strategies to optimize emergency clinician's use of adult and paediatric sepsis pathways.

Design: A qualitative descriptive study using focus group methodology.

Methods: Twenty-two emergency nurses and ten emergency medical officers from four Australian EDs participated in eight virtual focus groups.

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This Letter presents results from a combination of searches for Higgs boson pair production using 126-140  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV recorded with the ATLAS detector. At 95% confidence level (CL), the upper limit on the production rate is 2.9 times the standard model (SM) prediction, with an expected limit of 2.

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This Letter presents the first study of the energy dependence of diboson polarization fractions in WZ→ℓνℓ^{'}ℓ^{'}(ℓ,ℓ^{'}=e,μ) production. The dataset used corresponds to an integrated luminosity of 140  fb^{-1} of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector. Two fiducial regions with an enhanced presence of events featuring two longitudinally polarized bosons are defined.

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The global pet trade in invertebrates remains poorly understood and underrepresented in policy and research. Tarantulas are a highly traded invertebrate group. Many individuals in trade are wild caught, and trade regulation is often lacking, raising concerns about the effect of trade on local ecosystems and populations.

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Unlabelled: Person-centred care is an international healthcare priority. Strategies are needed to support nurses and midwives to understand the meaning of person-centredness and support them to embed this philosophy into practice. Clinical supervision has been proposed as a strategy to support this but requires more evidence.

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Statistical combinations of searches for charginos and neutralinos using various decay channels are performed using 139  fb^{-1} of pp collision data at sqrt[s]=13  TeV with the ATLAS detector at the Large Hadron Collider. Searches targeting pure-wino chargino pair production, pure-wino chargino-neutralino production, or Higgsino production decaying via standard model W, Z, or h bosons are combined to extend the mass reach to the produced supersymmetric particles by 30-100 GeV. The depth of the sensitivity of the original searches is also improved by the combinations, lowering the 95% C.

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What Is This Summary About?: This summary describes how researchers worked with people with multiple sclerosis (MS), neurologists and measurement experts to create an easy-to-use questionnaire to measure the physical function of people with MS. This questionnaire covers topics that are relevant and important to people with MS and their doctors.The ability to do what you want to do, when you want to do it, is one of the most important concerns for people with MS.

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Article Synopsis
  • GRT-X, a compound targeting mitochondrial translocator protein (TSPO) and Kv7.2/3 potassium channels, has been shown to aid recovery from cervical spine injuries, promoting axonal growth in dorsal root ganglion (DRG) neurons.
  • When tested on DRG explants from wild-type and TSPO knockout mice, GRT-X significantly stimulated axonal growth, while targeting TSPO with agonist XBD173 had delayed effects and activators/inhibitors of Kv7 channels reduced growth.
  • The compound GRT-X increased gene expression related to axonal growth and myelination in co-cultures, but its effects were lost in TSPO knockout cultures, suggesting other mechanisms involved that need further exploration
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Article Synopsis
  • * The measurements utilized both semileptonic and hadronic decays of top quarks, along with events focused on single top quark production in the electroweak t channel.
  • * The combined result for the top quark mass is 172.52 GeV, with a reduced total uncertainty of 0.33 GeV, showcasing an improvement of 31% over previous measurements.
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Article Synopsis
  • * The initiative has formed four working groups aimed at enhancing research, clinical management, eHealth, and healthcare system reforms, ensuring a collaborative effort among patients, caregivers, and other stakeholders.
  • * As it progresses, the initiative plans to boost the use of eHealth tools and passive PROs in research and clinical settings, while also refining statistical methods in clinical trials and fostering alignment among industry, regulatory bodies, and health policymakers regarding PROs in MS healthcare.
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Aim: The focus of this paper is to provide a detailed ethnographic exploration of rural nurses' experiences of their resuscitation preparedness and the subsequent post-resuscitation period.

Design: An ethnographic study across two small rural hospital sites in New South Wales, Australia.

Methods: Fieldwork was undertaken between December 2020 and March 2022 and included over 240 h of nonparticipant observation, journalling and interviews.

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