Publications by authors named "Micky Daniel Tortorella"
The human skeleton is renewed and regenerated throughout life, by a cellular process known as bone remodeling. Stem cells are clono-genic cells that are capable of differentiation into multiple mature cell types (multipotency), and simultaneously replenishing stem cell pool (self-renewal), which allows them to sustain tissue development and maintenance. Circulating mesenchymal stromal/stem cells (MSCs), are mobile adult stem cells with specific gene expression profiling, as well as enhanced mitochondrial remodeling as a promising source for personalized cell and gene therapy.
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- Extended pluripotent stem cells (EPSCs) can develop into both embryonic tissues and extraembryonic tissues, making them valuable for research and industry, but creating them from human cells has been challenging.
- A new culture medium called OCM175 was developed, which optimally includes ingredients like L-selenium-methylcysteine and ROCK inhibitors, allowing for feeder-free generation of EPSCs from human Urine-Derived Cells (hUC-iPSCs).
- The successful conversion of these cells into EPSCs shows their potential to contribute to various cell lineages, supporting advancements in regenerative medicine.