Publications by authors named "Mickael Choury"
Article Synopsis
- Medium-sized heterocycles (8 to 11 atoms) are crucial for many biologically active natural compounds and hold promise in medicinal chemistry, yet their use in research is limited due to synthesis challenges.
- The review discusses the synthesis of these heterocycles through transition-metal-catalyzed intramolecular cyclization, which, despite various difficulties, is a straightforward and effective approach.
- The synthesis methods are categorized based on the type of metal used (such as palladium, copper, gold, and silver) and further divided by the bond type formed, whether carbon-carbon or carbon-heteroatom.
A new tandem palladium-catalyzed reaction involving a Suzuki-Miyaura coupling, a desulfenylative coupling, and a hydrothiolation of a triple bond is reported. Notably, the desulfenylative coupling occurs without copper(I) assistance and the hydrothiolation is totally regioselective and stereoselective. The overall process results in the double incorporation of the boronic acid and the reincorporation of the sulfenyl moiety into the product structure.
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