Publications by authors named "Mickael Begue"
Article Synopsis
- Metallic nanoparticles (NPs), specifically core-shell FeO@Au NPs, were evaluated for their effects on human pulmonary mesenchymal stem cells (HPMSCs), showing no impact on cell viability at a concentration of 100 µg/mL.
- Gene expression in HPMSCs was altered after exposure, with significant changes noted at 72 hours, including decreased proinflammatory cytokines, but no effects on certain key tumor-related gene expressions.
- The study concluded that FeO@Au NPs do not harm HPMSCs and may be a promising method for targeted delivery to tumors alongside radiation therapy.
Introduction: Prostate cancer is the fourth most commonly diagnosed cancer among men worldwide. Various tools are used to manage disease such as conventional radiotherapy. However, it has been demonstrated that large prostate volumes were often associated with higher rates of genitourinary and gastrointestinal toxicities.
View Article and Find Full Text PDFMesenchymal stem/stromal cells (MSCs) are multipotent cells involved in numerous physiological events, including organogenesis, the maintenance of tissue homeostasis, regeneration, or tissue repair. MSCs are increasingly recognized as playing a major, dual, and complex role in cancer pathophysiology through their ability to limit or promote tumor progression. Indeed, these cells are known to interact with the tumor microenvironment, modulate the behavior of tumor cells, influence their functions, and promote distant metastasis formation through the secretion of mediators, the regulation of cell-cell interactions, and the modulation of the immune response.
View Article and Find Full Text PDFPurpose: To evaluate the efficacy and toxicity of high-dose-rate (HDR) brachytherapy in patients with inoperable endobronchial carcinoma.
Methods And Materials: We retrospectively reviewed the records (April 1991-May 2004) of patients with non-small-cell carcinoma, with no extrabronchial spread on computed tomography scans, who underwent HDR brachytherapy because of contraindications to surgery and external beam radiation therapy. Kaplan-Meier survival curves were compared by the log-rank test.