Publications by authors named "Michiyoshi Minato"
Article Synopsis
- - Baloxavir marboxil, an anti-influenza drug approved in Japan, can be less effective due to changes in the PA protein of viruses, particularly after treatment.
- - During the 2022-2023 season, most detected influenza cases were of subtype A(H3N2), with a small number showing mutations that reduce susceptibility to baloxavir even before treatment.
- - After treatment, some viruses developed significant PA substitutions, leading to similar symptom durations but delayed viral clearance, highlighting the importance of continuous monitoring for antiviral effectiveness.
Article Synopsis
- The study examined the fever duration in children infected with different influenza viruses (A(H1N1)pdm09, A(H3N2), and influenza B) and treated with either baloxavir marboxil or neuraminidase inhibitors (NAIs) over two influenza seasons in Japan.* -
- Among the 1,742 children analyzed, baloxavir showed a shorter median duration of fever compared to oseltamivir for A(H1N1)pdm09 but not in multivariable analyses, while no significant differences were found for A(H3N2) infections.* -
- For influenza B, baloxavir was notably more effective, reducing fever duration by approximately 15 hours compared to
Background: This study assessed the differences in daily virus reduction and the residual infectivity after the recommended home stay period in Japan in patients infected with influenza and treated with baloxavir (BA), laninamivir (LA), oseltamivir (OS), and zanamivir (ZA).
Methods: We conducted an observational study on children and adults at 13 outpatient clinics in 11 prefectures in Japan during seven influenza seasons from 2013/2014 to 2019/2020. Virus samples were collected twice from influenza rapid test-positive patients at the first and second visit 4-5 days after the start of treatment.
Article Synopsis
- A study was conducted to compare the effectiveness of baloxavir marboxil and oseltamivir in treating children with influenza A and B, focusing on the duration of fever and symptoms.
- The research included 159 patients under 19 years old from Japan during the 2019-2020 flu season, using specific statistical methods to analyze the data.
- Results indicated that the duration of fever was shorter for patients treated with baloxavir compared to those treated with oseltamivir, though further evaluation on baloxavir’s effectiveness and virus susceptibility is needed.
Human fetuses have markedly low levels of serum lipids and a unique lipoprotein profile with respect to quality, with low-density lipoprotein (LDL)-like particle as the dominant cholesterol carrier. However, little is known about triglyceride (TG) distribution. In addition, lipid metabolism is important in lung development, with indications that TG from very low-density lipoprotein (VLDL) is essential for surfactant synthesis.
View Article and Find Full Text PDFAim: To investigate whether end-tidal CO(2) monitoring is useful for more rapid recognition of tracheal vs. esophageal intubation as compared to standard clinical evaluation in very low birth weight infants during neonatal resuscitation at birth.
Patients And Methods: Forty infants were prospectively identified.
Background: The aim of the present paper was to investigate the effect of initial hemoglobin level on red blood cell transfusion and neonatal adaptation in extremely low-birthweight (ELBW) infants.
Methods: Subjects consisted of 54 ELBW infants admitted to level III neonatal intensive care unit between 1995 and 2000, and divided into two groups based on hemoglobin level at birth. High hemoglobin was defined as hemoglobin > or =15.
Background: The purpose of the present study was to evaluate the usefulness of serum S100B as a clinical marker of intracranial lesions in newborns.
Methods: The study involved 22 normal and 40 diseased newborns. Serum S100B level was measured on days 1 and 6 in normal newborns.
Background: Several subclasses of HDL are demonstrated to have different roles in atherosclerosis based on adult studies, but the significance of HDL heterogeneity in the fetus and neonate has not been clarified. It has been described that the cholesterol supply from apoE-rich HDL is essential for central nerve system neuron growth.
Methods: Sixty-five healthy, term, appropriate for gestational age neonates (38 males and 27 females) were included in the study.
In term neonates, the adiponectin concentration is higher than it is in adults. To determine the relationship between adiponectin and early neonatal growth in a cohort study. Fifty-two neonates at term were studied.
View Article and Find Full Text PDFBackground: The purpose of the present paper was to detect the clinical factors most predictive of red blood cell (RBC) transfusion in extremely low-birthweight (ELBW) infants in the recombinant human erythropoietin era.
Methods: Between 1995 and 2000, 66 ELBW infants were admitted to a level III neonatal intensive care unit. Fifty-four of 66 infants were eligible for enrollment in the present study.
We describe a case of cord blood harvest for autologous transfusion in a neonate weighing 3,992 g with a giant sacrococcygeal teratoma. The umbilical vein was pierced with an 18-gauge needle, and placental blood was withdrawn into two 50-ml syringes filled with 4 ml of citrate-phosphate-dextrose solution. Resection of the sacrococcygeal teratoma was performed on day one.
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