A Case of Generalized Pustular Psoriasis with Organizing Pneumonia During Treatment for Rheumatoid Arthritis.

Generalized pustular psoriasis (GPP) is a disease that presents with fever and multiple sterile pustules on flushed skin all over the body. GPP should be considered as systemic inflammatory response syndrome (SIRS), and is occasionally associated with respiratory failure. We encountered a case of GPP with organizing pneumonia (OP) during treatment for rheumatoid arthritis (RA).

Epidemiological analysis of the patients with psoriasis in Asian countries and region using the same clinical case cards between 2020 and 2022.

Although many epidemiological surveys for patients with psoriasis have been reported based on individual countries or facilities, there has been no study encompassing the major countries or the region in Asia. The Asian Society for Psoriasis (ASP) has been conducting an epidemiological study across various Asian countries and regions to elucidate the and compare the epidemiology of psoriasis. A total of 1948 cases were analyzed, with 938 cases from Japan, 530 cases from China, 325 cases from Korea, 141 cases from Chinese Taipei, and 14 cases from Thailand, all of which were enrolled between 2020 and 2022.

A Case of Disseminated Cutaneous Sporotrichosis Mimicking Sarcoidosis, that Required Four Biopsies to Diagnose.

A 69-year-old Japanese woman visited Tokai University Oiso hospital with cutaneous ulcers on her left upper arm that appeared in January 2013, and on her right nose that appeared in December of 2013. Neither the two biopsies and tissue culture from the arm lesion nor the biopsy and tissue culture from the nose lesion detected any organism. In December of 2013, she was diagnosed as cutaneous sarcoidosis at Oiso hospital and treated with oral prednisolone for six months, however, did not show improvement.

Zinc Deficiency with Cheilitis: A Report of Five Cases.

Zinc deficiency has long been known as acrodermatitis enteric dermatitis (congenital zinc deficiency). On the other hand, acquired zinc deficiency has attracted attention as a familiar disease in recent years. Epidemiological studies in Japan have shown that acquired zinc deficiency is more common than expected.

Case of Wound Myiasis in a Squamous Cell Carcinoma Lesion of the Scalp.

Myiasis refers to the infestation of living humans and vertebrate animals by dipterous larvae. Many organs can be infested by fly larvae, but cutaneous and wound myiases are the most frequently encountered clinical forms. Persistent ulcer or non-healing wound is one of the symptoms of squamous cell carcinoma which is the second most common skin cancer in the world.

Biological Retention Rates, the Reasons of Switching, and Prognostic Factors in Patients with Psoriasis Treated Biologics.

Objective: To review patients who were treated at Tokai University Hospital with biologic agents for psoriasis vulgaris and psoriatic arthritis and analyze the biological retention rate, reasons for switching biologics, and investigate possible clinical prognostic factor which may affect whether a patient preferred one biologic to another.

Methods: Clinical courses of 63 patients who received biologic agents between Sep of 2010 to June of 2019 were investigated. Biological retention rate of each biologic agents, reasons of switching to another biologic agent, and prognostic factors, if any, between switched and non-switched patients were examined.

New Treatment Addressing the Pathogenesis of Psoriasis.

Psoriasis is an immune cell-mediated inflammatory skin disease. The interleukin (IL)23/IL17 axis plays an important role in the development of psoriasis. The effectiveness of biologic treatments such as tumor necrosis factor (TNF)α inhibitors (infliximab, adalimumab, certolizumab pegol), IL23 inhibitors (ustekinumab, guselkumab, tildrakizumab, risankizumab), and IL17 inhibitors (secukinumab, ixekizumab, brodalumab) have verified these findings.

Analyses of kinetic glass transition in short-range attractive colloids based on time-convolutionless mode-coupling theory.

For short-range attractive colloids, the phase diagram of the kinetic glass transition is studied by time-convolutionless mode-coupling theory (TMCT). Using numerical calculations, TMCT is shown to recover all the remarkable features predicted by the mode-coupling theory for attractive colloids: the glass-liquid-glass reentrant, the glass-glass transition, and the higher-order singularities. It is also demonstrated through the comparisons with the results of molecular dynamics for the binary attractive colloids that TMCT improves the critical values of the volume fraction.

Pediatric case of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma forming a solitary skin tumor on the forearm.

A 5-year-old girl noticed a rapidly growing reddish nodule on her right forearm. Although oral antibiotics had been administrated for 2 weeks, the tumor enlarged. Skin biopsy revealed excessive infiltration of atypical neoplastic cells expressing CD4, CD30 and anaplastic lymphoma kinase (ALK).

Comparison of mode-coupling theory with molecular dynamics simulations from a unified point of view.

We study the tagged-particle dynamics by solving equations of the mode-coupling theory (MCT). The numerical solutions are compared with results obtained by the molecular dynamics (MD) simulations from a unified point of view proposed by Tokuyama [Phys. Rev.

Universality in self-diffusion of atoms among distinctly different glass-forming liquids.

The long-time self-diffusion coefficients D(S)(L) in distinctly different glass-forming liquids are analyzed from a unified point of view recently proposed by the present author. It is shown that as long as the systems are in equilibrium, they are all described by the following two types of master curves, depending on whether the control parameter is intensive or extensive: D(S)(L)(x) = d(0)x(-1)(1 - x)(2+η) exp[cx(3+η)(1 - x)(2+η)] for a reduced intensive control parameter x, such as a reduced inverse temperature, and D(S)(L)(x) = d(0)x(-1)(1 - x)(2) for a reduced extensive control parameter x, such as a reduced volume fraction, where d(0) and c are constant. Here, the exponent η (≠0) results from many-body correlations in a supercooled liquid state.

Self-diffusion of biomolecules in solution.

A simple soft-core model potential is proposed to discuss the self-diffusion of biomolecules in solution. Extensive Brownian-dynamics simulations are performed to obtain the long-time self-diffusion coefficient. Then the simulation results are compared with the experimental data from a unified point of view recently obtained for suspensions of hard spheres.

Dynamics of a single atom in ternary metallic glass-forming Cu₆₀Ti(x)Zr(40-x) melts by molecular-dynamics simulations.

The recently proposed universality near the glass transition [M. Tokuyama, Phys. Rev.

Single master curve for self-diffusion coefficients in distinctly different glass-forming liquids.

An existence of a single master curve for the long-time self-diffusion coefficients D(S)(L)(T) in diversely different glass-forming liquids is predicted over wide temperature T ranges above the glass transition point T(g) by analyzing various experimental and simulation data consistently from a unified point of view based on the mean-field theory recently developed. In order to scale those data appropriately, the power-law dependence of the α- and the β-relaxation times on D(S)(L) is used. Then, it is shown that any equilibrium data for self-diffusion of atom in different systems are all collapsed onto a singular function f(T(f)((α))/T) , where T(f)((α)) is a fictive singular temperature of atom α.

Universality in multicomponent glass-forming liquids near the glass transition.

The slow dynamics of a single particle in multicomponent glass-forming systems including fragile and strong glasses is studied from a unified point of view. The simulation results on two different systems, bulk glass-forming Cu60Ti20Zr20 melt and network-forming SiO2 , melt are analyzed by the mean-field theory (MFT) recently proposed and are compared with other systems near the glass transition. It is shown that the simulation results for the mean-square displacement are all collapsed into a master curve given by MFT if a long-time self-diffusion coefficient has the same value in each system.

Slow dynamics and re-entrant melting in a polydisperse hard-sphere fluid.

Extensive molecular dynamics simulations are performed at 6% polydispersity to investigate the phase diagram of a polydisperse hard-sphere fluid and the dynamical behavior in each phase. As the volume fraction phi is increased, the existence of a supercooled liquid is suggested above phi = 0.5524 by the mean-field analysis proposed recently.

Test of mean-field equations for two types of hard-sphere systems by a Brownian-dynamics simulation and a molecular-dynamics simulation.

A mean-field nonlinear equation for the mean-square displacement, recently proposed by one of the present authors [M. Tokuyama, Phys. Rev.