[Drug therapy for AD/HD investigation of usefulness of extended-release methylphenidate and atomoxetine from the viewpoint of persistency rate].

Objective: Currently, extended-release methylphenidate (MPH) and atomoxetine (ATX) are used for the medical treatment of AD/HD. The purpose of this study is to investigate the current state of these treatments from the viewpoint of the persistency rate of each drug.

Methods: Of patients who had AD/HD or pervasive developmental disorder (PDD) associated with the symptoms of AD/HD, 460 cases who receiving MPH and 121 receiving ATX were investigated in terms of the diagnosis, the persistency rate, the persistency rate by the diagnostic name, reasons for discontinuation, and concomitant drugs as continual medications.

[Care continuity for patients with attention deficit hyperactivity disorder (ADHD) during transition from childhood to adulthood].

It is necessary to understand a basic condition of ADHD and then, to aim at the improvement of communications skills, to guide that it is possible to orient oneself to the community, and to bring up confidence and self-esteem as well as the puerility since adolescence. When the relief of symptoms is strongly hoped because the core symptom remains or there are a concomitant trouble and coexisting illness even if young person or adult, the central nerve stimulus is also necessary as well as the puerility.

[Clinical assessment of the effect of switch from immediate-release to extended-release methylphenidate in 181 patients with isolated attention deficit/hyperactivity disorder (AD/HD) or AD/HD associated with pervasive developmental disorder].

We switched medication from conventional immediate-release preparations of methylphenidate to extended-release tablets (an osmotic release oral system) in 165 of 181 cases with attention deficit/hyperactivity disorder (AD/HD), in accordance with the revised indications for these tablets. We investigated the types of developmental disorders, doses of the drug, efficacy, adverse effects, concomitant medication, other relevant problems, and so on, prior to switching the medications. The most common types of developmental disorders were AD/HD with symptoms of pervasive developmental disorder (PDD) and PDD with symptoms of AD/HD.

Symptomatic parieto-occipital epilepsy as sequela of perinatal asphyxia.

Perinatal hypoxic-ischemic encephalopathy in term infants has been well-documented as a cause of selective brain damage over the parasagittal brain regions in cases of partial asphyxia. We describe 10 patients (7 boys, 3 girls) who developed normally after perinatal asphyxia, and who later experienced parieto-occipital epilepsy. We retrospectively reviewed medical records, electroencephalograms, and neuroimaging findings.