Evaluation of the Variability of Ambient Interactive Zippy Estimation of Sequential Rapid Tests on the "imo" Perimeter in Patients With Stable Glaucoma.

Prcis: Analysis of Ambient Interactive Zippy Estimation of Sequential Testing (AIZE) Rapid test variability in patients with stable glaucoma showed that the 95% prediction interval of the mean deviation (MD) value, potentially an index for judging progression, was ±1.63 to ±1.78 dB in early-to-moderate-stage patients.

Association of , and Polymorphisms With Osimertinib-induced Adverse Events in NSCLC Patients.

Background/aim: Osimertinib is a key drug for treating epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). Genetic differences may be associated to adverse events (AEs) induced by osimertinib. This retrospective observational multicenter study evaluated the association of genotypes, including STAT3 -1697C>G, CYP3A5 6986A>G, and ABCG2 421C>A, with the incidence of osimertinib-induced AEs in patients with EGFR mutation-positive NSCLC.

Effectiveness of pharmacist intervention for deprescribing potentially inappropriate medications: a prospective observational study.

Background: Potentially inappropriate medications (PIMs) and polypharmacy in older adults lead to increase the risk of adverse drug events. This study aimed to evaluate the effectiveness of pharmacist intervention combining the criteria for detecting PIMs with the deprescribing algorithm on correcting PIMs, reducing the number of medications, and readmissions.

Methods: A prospective observational study was conducted at a Japanese University Hospital enrolling new inpatients aged ≥65 years prescribed ≥1 daily medication.

Influence of drying of chara cellulose on length/length distribution of microfibrils after acid hydrolysis.

Chara is a genus of freshwater alga that is evolutionarily observed at the aquatic-terrestrial boundary, whose cellulose microfibrils are similar to those of terrestrial plants regarding the crystallinity and biosynthesis of cellulose. Oven-dried and never-dried celluloses samples were prepared from chara. Terrestrial plant cellulose samples were used as references.

Fast and Robust Nanocellulose Width Estimation Using Turbidimetry.

The dimensions of nanocelluloses are important factors in controlling their material properties. The present study reports a fast and robust method for estimating the widths of individual nanocellulose particles based on the turbidities of their water dispersions. Seven types of nanocellulose, including short and rigid cellulose nanocrystals and long and flexible cellulose nanofibers, are prepared via different processes.

Hydrophobic, ductile, and transparent nanocellulose films with quaternary alkylammonium carboxylates on nanofibril surfaces.

Hydrophobic, ductile, and transparent nanocellulose films were prepared by casting and drying aqueous dispersions of 2,2,6,6-tetramethylpiperidine-1-oxyl-oxidized cellulose nanofibrils (TOCNs) with quaternary alkylammoniums (QAs) as counterions for the surface carboxylate groups. TOCN films with tetramethylammonium and tetraethylammonium carboxylates showed high optical transparencies, strain-to-failure values (14-22%), and work-of-fracture values (20-27 MJ m(-3)). The ductility of these films was likely caused by the alkyl chains of the QA groups densely covering the TOCN surfaces and being present at the interfaces between the TOCN elements in the films.

Bulky quaternary alkylammonium counterions enhance the nanodispersibility of 2,2,6,6-tetramethylpiperidine-1-oxyl-oxidized cellulose in diverse solvents.

The degree of nanodispersion of cellulose in diverse solvents is a significant primary criterion for the preparation of bulk nanocelluloses and nanocellulose-containing composites. Here, high degrees of nanodispersion of fibrous 2,2,6,6-tetramethylpiperidine-1-oxyl-oxidized cellulose (TOC) were achieved in various solvents by efficiently incorporating quaternary alkylammoniums (QAs) as counterions of TOC carboxyl groups via simple ion-exchange treatment in water. Tetramethyl-, tetraethyl-, tetra-n-propyl-, and tetra-n-butylammoniums were used as the QAs.

Preparation and characterization of TEMPO-oxidized cellulose nanofibrils with ammonium carboxylate groups.

Fibrous TEMPO-oxidized celluloses with 100% ammonium carboxylate groups (TOC-COONH4) were prepared by adding aqueous ammonia to fibrous TOC-COOH/water slurries. Using a gentle mechanical disintegration treatment in water, the obtained never-dried TOC-COONH4/water slurries could be converted to highly viscous and transparent gels consisting of mostly individualized TEMPO-oxidized cellulose nanofibrils. The self-standing TOCN-COONH4 film prepared from the aqueous TOCN-COONH4 dispersion via casting and drying had high optical transparency.

The spindle pole body of the pathogenic yeast Exophiala dermatitidis: variation in morphology and positional relationship to the nucleolus and the bud in interphase cells.

The spindle pole body (SPB) in the interphase cell of the pathogenic yeast Exophiala dermatitidis was studied in detail. The SPB was located on the outer nuclear envelope and was 342 +/- 86 nm long in a haploid strain. It consisted of two disk elements that measured 151 +/- 43 nm in diameter and 103 +/- 17 nm in thickness, connected by a rod-shaped midpiece that measured 56 +/- 20 nm in length and 37 +/- 9 nm in diameter.

A survey on low-dose oral contraceptive transactions at pharmacies.

Low-dose oral contraceptives (OCs) were approved by the Japanese Ministry of Health, Labor and Welfare in 1999. However, few women use low-dose OCs (married 1.9%, unmarried 0.