Publications by authors named "Michiko Kandori"
Background: Corneal endothelial cells are known to be targets of herpes simplex virus type 1 (HSV-1) infection; however, the pathogenesis of HSV infections of the endothelial cells has not been definitively determined. The purpose of this study was to examine an unrecognised strategy of corneal endothelial cells to protect themselves from HSV-1 infection.
Methods: Immortalised human corneal endothelial cells (HCEn) were infected with HSV-1.
Aims: The purpose of this study is to elucidate the clinical manifestations and the current treatment status of cytomegalovirus (CMV) endotheliitis via a large case series obtained from a national survey conducted in Japan.
Methods: The Japan Corneal Endotheliitis Study Group proposed diagnostic criteria for CMV endotheliitis based on a viral examination by PCR of aqueous humour, in combination with clinical manifestations. A national survey was then retrospectively conducted among 1160 members of the Japan Cornea Society.
Article Synopsis
- The study aimed to analyze cytomegalovirus (CMV)-related inflammation in the eye's front section and assess if CMV levels correlate with disease characteristics.
- In a review of 73 patients with stubborn anterior segment inflammation, CMV DNA was found in 24 cases, showing a link between CMV levels and factors like recurrent episodes and glaucoma treatments.
- High levels of CMV DNA were identified as significant risk factors for increased intraocular pressure (IOP), presence of specific lesions, recurrent inflammation, and reduced endothelial cell density, emphasizing the importance of DNA measurement in determining inflammation severity.
Aims: To determine the efficacy of a new helicase-primase inhibitor, ASP2151, for treating herpetic keratitis.
Methods: Murine corneas were infected with herpes simplex virus type 1 (HSV-1). ASP2151 was administered orally or topically, and the severity of epithelial dendritic keratitis was determined.
Article Synopsis
- The study reports on 4 cases of Acanthamoeba keratitis that did not respond to standard medical treatments and were instead treated with excimer laser phototherapeutic keratectomy (PTK).
- PTK effectively removed the infected corneal lesions, leading to a quick resolution of symptoms and no recurrence post-surgery, although slight additional ablation was necessary.
- The conclusion suggests that PTK is an effective treatment option for certain cases of Acanthamoeba keratitis, particularly when the infection is limited to the superficial layer of the cornea, as it allows for better visual recovery and reduces the risk of irregular astigmatism.
Purpose: To assess corneal scrapings and aqueous humor samples analyzed by polymerase chain reaction (PCR) that were positive for cytomegalovirus (CMV) in patients with keratitis of unknown origin and to investigate their clinical manifestations.
Design: Retrospective, interventional case series.
Participants: Seventy-eight patients with epithelial (n=37), stromal (n=12), or endothelial keratitis (n=29) of unknown origin examined at the Osaka University Medical Hospital.
Purpose: To report 2 cases of Acanthamoeba keratitis whose causative pathogen was detected only by real-time polymerase chain reaction (PCR).
Methods: Histological examinations of corneal scrapings were stained with Fungiflora Y. Corneal scrapings were also cultured on nonnutrient agar.