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Publications by authors named "Michiko Iwata"

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Genome-scale CRISPR-Cas9 screen identifies host factors as potential therapeutic targets for SARS-CoV-2 infection.
Madoka Sakai Yoshie Masuda Yusuke Tarumoto Naoyuki Aihara Yugo Tsunoda Michiko Iwata

iScience

August 2024

Article Synopsis
  • The study identifies specific host factors, such as TRIM28, TRIM33, EHMT1, and EHMT2, that are crucial for SARS-CoV-2 infection by using CRISPR-Cas9 screening.
  • TRIM28 may help with the formation of viral particles, while TRIM33, EHMT1, and EHMT2 are likely involved in the virus's transcription and replication processes.
  • The compound UNC0642, which inhibits the activity of EHMT1/2, demonstrated significant potential in reducing SARS-CoV-2 growth and disease severity in test models.
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[Pharmacological properties of abiraterone acetate (ZYTIGA® tablet 250 mg), a new drug for the treatment of castration-resistant prostate cancer, and results of its clinical studies].
Michiko Iwata Kenichiro Tsutsumi Yasushi Harada

Nihon Yakurigaku Zasshi

May 2015

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[Pharmacological properties of rilpivirine (Edurant Tablet), a new drug for the treatment of HIV, and results of its clinical studies].
Michiko Iwata Koji Shikinami Kenji Nagino Yasushi Harada

Nihon Yakurigaku Zasshi

April 2013

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[Pharmacological and clinical profile of Etravirine (Intelence)].
Michiko Iwata Hideji Fujii Shinya Yoshida Yasushi Harada

Nihon Yakurigaku Zasshi

October 2009

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[Pharmacological and clinical profile of Darnavir (Prezista)].
Michiko Iwata Shinya Yoshida Yasushi Harada

Nihon Yakurigaku Zasshi

December 2008

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