Publications by authors named "Michiko Haida"
Basophil activation test (BAT) is an in vitro allergy test that is useful to identify allergens that cause IgE-dependent allergies. The test has been used to detect not only food allergies and allergies caused by environmental factors but also to detect drug hypersensitivity, which has been known to include IgE-independent reactions. In our preliminary studies in which BAT was applied to detect hypersensitivity of loxoprofen, a non-steroidal anti-inflammatory drug (NSAID), conventional BAT with incubation for 30min did not show basophil activation by means of increased CD203c expression.
View Article and Find Full Text PDFPeople living in Japan were affected in various ways after the Great East Japan earthquake of March 11, 2011. A 52-year-old female asthma patient not directly affected by the disaster experienced a decrease in peak expiratory flow (PEF) immediately after the earthquake. Despite increasing the inhaled and oral corticosteroid doses, her PEF did not recover.
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- Indacaterol is an inhaled, long-acting beta-2 agonist being developed for asthma treatment, and this study focused on its 24-hour effectiveness compared to placebo in Japanese patients.
- In a randomized, placebo-controlled trial involving 41 patients, all doses of indacaterol (150, 300, and 600 μg) demonstrated significantly greater bronchodilation than placebo, with more rapid effects observed compared to salmeterol at short time points.
- The study concluded that indacaterol provides sustained bronchodilation with a faster onset and similar safety profile to placebo, showing consistency with previous research in other populations.