Carpal and tarsal osteolysis.

A 34-year-old male is reported with carpal and tarsal osteolysis syndrome. In addition he presented a fluctuating proteinuria and a slightly reduced renal function. The relevant literature on the subject is reviewed and the combination of carpal and tarsal osteolysis with nephropathy is discussed.

Silicon nephropathy: a possible occupational hazard.

A 37-year-old white male, working in a tile factory, presented proteinuria with no obvious tubular dysfunctional. Renal biopsy disclosed a mild focal segmental proliferative glomerulonephritis. Distinct alterations were found by electron microscopy, especially in the proximal tubular cells.

An unusual case of lymphocele after renal transplantation. Case report.

A patient who developed a lymphocele five years after renal transplantation is presented and discussed.

[Problems of wound healing during kidney transplantation (author's transl)].

Infection of the transplant bed caused an important morbidity and mortality. Meticulous preoperative preparation and surgical technique, the local irrigation of the transplant site with local antibiotics as well as the barrier-nursing of these high risk patients are all equally important factors to limit infectious complications in the transplant population. Since the use of the barrier-nursing principle, infection rate fell down from 8.

Glomerulonephritis in late-onset cystinosis. Report of two cases and review of the literature.

This paper describes the clinical history of two male nontwin siblings with late-onset cystinosis, a variant of cystine storage disease. The diagnosis was established clinically and confirmed by measurement of cystine concentrations in leucocytes and skin-fibroblasts. Both patients presented with an incomplete nephrotic syndrome and renal biopsy showed, in addition to lesions of polykaryocytosis, a picture of focal and segmental glomerular hyalinosis.

Significance of urinary excretion of fibrin degradation products during treatment of glomerulonephritis.

189 patients with various types of glomerular disease were studied. Creatinine clearance, protein excretion and urinary excretion of fibrin degradation products (FDPs) were measured before and at various intervals (up to 42 months) after starting treatment with indomethacin, alone or in combination with other drugs. The following observations were made: a.

Bartter's syndrome with hyperplasia of renomedullary cells: successful treatment with indomethacin.

During treatment with indomethacin in a patient with Bartter's syndrome, hypokalemia, high plasma renin concentration, hyperaldosteronism and decreased sensitivity to angiotensin infusion were corrected. A particular finding in the renal biopsy specimen was a marked hyperplasia of renomedullary interstitial cells which had characteristics similar to the cells known to produce renal prostaglandins. The hypothesis is formultated that the primary defect in this syndrome is related to hyperplasia of renomedullary interstitial cells and inappropriate release of renal prostaglandins giving rise to decreased sodium reabsorption, volume depletion and hypersecretion of renin and aldosterone.

Treatment of chronic glomerulonephritis with a combination of indomethacin and cyclophosphamide.

33 cases of chronic glomerulonephritis who responded unsatisfactorily to treatment with indomethacin alone were treated in addition with a low dose of cyclophosphamide. The five patients with focal glomerulosclerosis responded poorly. The remaining 28 patients showed a statistically significant improvement in renal function and proteinuria.

[Kidney preservation methods (author's transl)].

The results of preservation of the two kidneys of the same animal by two different techniques and then reimplanted on the same femoral artery, have been compared. The two methods are the following: 1) Short starting perfusion by Collins solution and than cold storage a 4 degrees C in the same solution. 2) Continuous perfusion by machine supplied by pulsatile pump, oxigenator, cooling.

Indomethacin and platelet aggregation in chronic glomerulonephritis: existence of non-responders.

Indomethacin given to adults with glomerulonephritis usually reduces their urinary excretion of protein and fibrinogen/fibrin-related (F.R.) antigen.