Publications by authors named "Michiel Aj Van De Sande"
Background: Children and young adults needing surgery for a primary malignant bone tumour around the knee face a difficult, life-changing decision. A previous study showed that this population wants to be involved more in the decision-making process and that more involvement leads to less decisional stress and regret. Therefore, a well-designed and standardized decision-making process based on the principles of shared decision-making needs to be designed, implemented, and evaluated.
View Article and Find Full Text PDFAim of this explorative pilot study was to evaluate the capability of an electronic nose (aeoNose, the eNose Company) to classify healthy individuals and patients with chondrosarcoma, based on their volatile organic compound profiles in exhaled breath. Fifty-seven patients (25 healthy controls, 24 chondrosarcoma and 8 different benign lesions) were included in the study from 2018 to 2023. An artificial neural network was used as classifier.
View Article and Find Full Text PDFAs simple as it sounds? The treatment of simple bone cysts in the proximal femur in children and adolescents: Retrospective multicenter EPOS study of 74 patients.
J Child Orthop
February 2024
Article Synopsis
- Simple bone cysts are common benign lesions in children, especially in the proximal femur, which have a higher fracture risk and lack clear treatment guidelines.* -
- A study examined 74 pediatric patients from various hospitals over 21 years, analyzing different treatment methods and their effects on recovery and complications.* -
- Results showed no definitive best treatment, as various methods had similar failure rates and recovery times; watchful waiting may be effective for some cases.*
Background And Purpose: Neoadjuvant (NRTX) and adjuvant radiotherapy (ARTX) reduce local recurrence (LR) risk in extremity soft tissue sarcoma (eSTS), yet their impact on distant metastasis (DM) and overall survival (OS) is less well defined. This study aimed at analysing the influence of NRTX/ARTX on all three endpoints using a retrospective, multicentre eSTS cohort.
Materials And Methods: 1200 patients (mean age: 60.
The aim of this pilot study was to assess whether an electronic nose can detect patients with soft tissue sarcoma (STS) based on volatile organic compound profiles in exhaled breath. In this cross-sectional pilot study, patients with primary STS and healthy controls, matched on sex and age, were included for breath analysis. Machine learning techniques were used to develop the best-fitting model.
View Article and Find Full Text PDFIntroduction: Metastasectomy is hypothesised to improve OS in metastatic STS, but evidence in favour of this approach derives from non-controlled single-arm cohorts affected by selection bias. The objective was to quantify the effect of metastasectomy vs. non-surgical management on overall survival (OS) in patients with metachronous metastases from extremity- and trunk soft tissue sarcoma (STS).
View Article and Find Full Text PDFArticle Synopsis
- - McCune-Albright syndrome (MAS) is a rare bone disorder that features fibrous dysplasia (FD), hormonal issues, and café-au-lait skin spots; patients with MAS often have a more severe form of the disease compared to those with polyostotic fibrous dysplasia (PFD).
- - A study assessed the outcomes of long-term bisphosphonate therapy in 11 MAS patients and 30 PFD patients, revealing that while many PFD patients responded well, only a small number of MAS patients showed significant improvement due to their higher disease severity and complications like precocious puberty and fractures.
- - The findings indicated that factors such as skeletal disease burden and specific biochemical markers (like FGF-23 and alkaline