Assessing age-related risks of gastrointestinal pathologies: a comparative study of gastroscopy outcomes across decades.

Background: Esophagogastroduodenoscopy (EGD) is the gold standard method for diagnosing upper gastrointestinal (GI) pathology. Swedish guidelines recommend patients over 50 years with new-onset dyspeptic symptoms undergo direct gastroscopy to rule out malignancy. However, the incidence of dysplasia or cancer in patients aged 61-70 years remains unclear.

A comparison of Swedish IBS patients and general practitioners regarding viewpoints on IBS: a Q-methodology study.

Objectives: Irritable bowel syndrome (IBS) is a common functional gastrointestinal condition. A respectful patient-doctor relationship with good communication is crucial for optimal treatment. Q-methodology is a combination of qualitative and quantitative methods used to study subjectivity.

Time and Motion at the Endoscopy Unit-A University Hospital Experience.

Background/aims: An effective workflow at the endoscopy unit is important for optimal production. We conducted a time-and-motion study to identify the amount of time that patients spend during the different steps of a regular endoscopy procedure and compared propofol with midazolam sedation.

Methods: Data from 376 patients were prospectively collected.

The effectiveness of the colorectal cancer referral pathway - identification of colorectal cancer in a Swedish region.

Introduction: To shorten the time for diagnosis of suspected colorectal cancer (CRC), a standardized colorectal cancer referral pathway (CCRP) was introduced in Sweden in September 2016. However, the effects of the CCRP are still uncertain, and CRC is also found in patients undergoing a routine colonoscopy.

Objective: To identify all CRC-cases in the Region Örebro County and to investigate which diagnostic pathway they were diagnosed.

Vectorial secretion of interleukin-8 mediates autocrine signalling in intestinal epithelial cells via apically located CXCR1.

Background: In the intestinal mucosa, several adaptations of TLR signalling have evolved to avoid chronic inflammatory responses to the presence of commensal microbes. Here we investigated whether polarized monolayers of intestinal epithelial cells might regulate inflammatory responses by secreting IL-8 in a vectorial fashion (i.e.

The effect of acute serotonergic modulation on rectal motor function in diarrhea-predominant irritable bowel syndrome and healthy controls.

Background: Irritable bowel syndrome (IBS) patients suffer from visceral hypersensitivity and show increased activity in the brain emotional arousal network following a rectal stimulus, compared with controls. Serotonergic activity can be decreased by acute tryptophan depletion (ATD), which increases visceral perception and also increases activity in the brain's emotional arousal network during rectal stimulation. Treatment with a serotonin reuptake inhibitor such as citalopram is effective in some IBS patients.

Acute tryptophan depletion slows gastric emptying in females.

Serotonin (5-HT) is an important neurotransmitter involved in the brain-gut axis. It is possible to lower the 5-HT level in the body by means of a nutritional intervention using an amino acid mixture; the acute tryptophan depletion (ATD) method. We studied the effect of ATD on gastric emptying in healthy females, who received both ATD and placebo in a random order.

Gastrointestinal profile of symptomatic athletes at rest and during physical exercise.

Some athletes suffer from exercise-induced gastrointestinal (GI) disturbances. We developed a profile of GI parameters in 10 symptomatic and 10 asymptomatic athletes both at rest and during exercise. Exercise included 90 min of cycling and running at 70% of maximal power.