A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome.

Following the Coronavirus disease 2019 (COVID-19) pandemic, a large number of people continue to report Post-COVID symptoms (PCS). A wide variety of symptoms are described, including fatigue, post-exertional malaise and cognitive impairment. However, adequate objective diagnostic tests for PCS are not yet available.

Late onset epilepsy and stroke: Diagnosis, pathogenesis and prevention.

The association of stroke and late-onset epilepsy (LOE) is discussed with special regard to its diagnosis, pathogenesis, and prevention. In addition to epidemiological data, including those from different age groups, the mechanisms for the development of acute symptomatic and remote symptomatic seizures are reviewed. The risk factors associated with seizures and post-stroke epilepsy (PSE) are considered, along with the methodological limitations of the study.

Improving Glaucoma Patients' Quality of Life and Adherence With a Digital Health Application: [RETRACTED].

Prcies: Empowering glaucoma patients to access their individual glaucoma related health data by using a digital health application leads to a significant improvement in quality of life and adherence.

Purpose: Evaluate the effectiveness of improvement of glaucoma associated quality of life and adherence in patients using a digital health application.

Patients And Methods: A prospective randomized monocentric controlled study of 77 patients with primary open angle glaucoma.

Virtual reality for assessing stereopsis performance and eye characteristics in Post-COVID.

In 2019, we faced a pandemic due to the coronavirus disease (COVID-19), with millions of confirmed cases and reported deaths. Even in recovered patients, symptoms can be persistent over weeks, termed Post-COVID. In addition to common symptoms of fatigue, muscle weakness, and cognitive impairments, visual impairments have been reported.

Retinal microvascular signs and recurrent vascular events in patients with TIA or minor stroke.

Background And Purpose: Retinal pathologies are an independent risk factor for ischaemic stroke, but research on the predictive value of retinal abnormalities for recurrent vascular events in patients with prior stroke is inconclusive. We investigated the association of retinal pathologies with subsequent vascular events.

Methods: In a substudy of the Intensified secondary prevention intending a reduction of recurrent events in TIA and minor stroke patients (INSPiRE-TMS) trial, we enrolled patients with recent transient ischaemic attack (TIA) or minor stroke with at least one modifiable risk factor.

Teleglaucoma Using a New Smartphone-Based Tool for Visual Field Assessment.

Prcis: COVID-19 underlines the importance of telemedical diagnostics. The smartphone-based campimetry (Sb-C) is a newly developed digital application allowing visual field testing using a head-mounted device and a smartphone. It enables visual field screening remotely from a clinic.

Shipbreaking in Bangladesh: Organizational responses, ethics, and varieties of employee safety.

Introduction: The dismantling of large ocean-going ships at the end of their productive use, or shipbreaking, has a poor reputation for employee safety in some developing countries. India and Bangladesh have recently come to dominate the global shipbreaking industry in terms of the tonnage of scrapped and recycled ships and the work is reportedly hazardous, posing significant ethical and practical risks to employee health and safety. This study aims to investigate the veracity of this reputation by identifying how different shipbreaking firms manage workplace safety, and their reasons for doing so.

Stereopsis Only: Validation of a Monocular Depth Cues Reduced Gamified Virtual Reality with Reaction Time Measurement.

The visual depth perception is composed of monocular and binocular depth cues. Studies show that in absence of binocular depth cues the performance of visuomotor tasks like pointing to or grasping objects is limited. Thus, binocular depth cues are of great importance for motor control required in everyday life.

[Binocular vision training for professional athletes].

Background: Optimal visual abilities including stereo acuity seem to be an important issue in sports. There is increasing evidence that stereo acuity can be sustainably improved by digital vision training even for people with good stereo acuity.

Study Design And Test Methods: In this study 31 male and female tennis players (professionals, young professionals, coaches and former professionals) completed at least 6 training units each with 192 dynamic stereoscopic tasks (N = 1152) within 6 weeks including a 4-option test with different levels of difficulty on a 3D screen at a distance of 5 m.

Hess Screen Revised: How Eye Tracking and Virtual Reality change Strabismus Assessment.

Strabismus is a visual disorder characterized by eye misalignment. The extent of ocular misalignment is denoted as the deviation angle. With the advent of Virtual Reality (VR) Head-Mounted-Displays (HMD) and eye tracking technology, new possibilities measuring strabismus arise.

Stereoscopic Visual Perceptual Learning in Seniors.

Background: We showed that seniors can improve their stereoscopic ability (stereoacuity) and corresponding reaction time with repetitive training and, furthermore, that these improvements through training are still present even after a longer period of time without training.

Methods: Eleven seniors (average age: 85.90 years) trained twice a week for six weeks with dynamic stereoscopic perception training using a vision training apparatus (c-Digital Vision Trainer).

Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.

Importance: Many cancer subtypes, including KIT-mutant gastrointestinal stromal tumors (GISTs), are driven by activating mutations in tyrosine kinases and may initially respond to kinase inhibitors but frequently relapse owing to outgrowth of heterogeneous subclones with resistance mutations. KIT inhibitors commonly used to treat GIST (eg, imatinib and sunitinib) are inactive-state (type II) inhibitors.

Objective: To assess whether combining a type II KIT inhibitor with a conformation-complementary, active-state (type I) KIT inhibitor is associated with broad mutation coverage and global disease control.

Diabetic Macular Edema in Diabetological Practices.

Using mobile OCT equipment and remote ophthalmological diagnosis of n = 1538 diabetics in 17 diabetes practices in Germany, we found diabetic macular edema in 10.1% of the patients and retinal bleedings or microaneurysms in 15.6%.

Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography.

Spectral-domain optical coherence tomography (SD-OCT) represents a reliable tool for retinal layer volume and thickness measurement. The aim of this study was to evaluate retinal changes indicating neurodegenerative processes in patients with end-stage renal disease (ESRD) compared to healthy controls. This was a cross-sectional, single-center study comprising 32 ESRD patients and 38 controls.

OCT and IOP findings in a healthy worker cohort: results from a teleophthalmic study in occupational medicine.

Purpose: To avoid significant loss of vision in employees, the working population could be examined with ophthalmic methods as OCT and IOP measurement for detection of serious eye diseases. The value of "virtual eye clinics" in occupational preventive medicine has been previously shown. We used a telemedical approach to gather epidemiological information about prevalence of eye diseases such as glaucoma, ocular hypertension, hypertensive retinopathy, diabetic retinopathy, epiretinal membrane, AMD, adult vitelliform maculopathy, cystoid maculopathy, choroidal nevi, and macular drusen.

Evidence of neurodegeneration in individuals with only mildly elevated blood pressure.

Objective: Initiation of antihypertensive drug treatment in low-risk individuals with grade 1 hypertension is under debate. The aim of this study was to examine the impact of mildly elevated blood pressure (BP) on early neurodegenerative processes independent of ageing.

Methods: Sixty-two individuals were included in this study: 25 young (aged <40 years) and 37 older (aged ≥40 years) individuals at low cardiovascular risk and grade 1 hypertension at most.

[Impairment of the Visual System in Glaucoma].

MR Diffusion Tensor Imaging (DTI) enables visualisation of the visual system in glaucoma; it has been shown that the atrophy of the optic radiation is more pronounced in glaucoma than in age-matched controls. The atrophy of the optic radiation thereby correlates with OCT and visual field measures. Diffusion tensor imaging permits quantification of the axonal integrity of the optic radiation by calculation of fractional anisotropy (FA) and radial diffusivity (RD).

Cerdulatinib Pharmacodynamics and Relationships to Tumor Response Following Oral Dosing in Patients with Relapsed/Refractory B-cell Malignancies.

Purpose: Preclinical studies suggest SYK and JAK contribute to tumor-intrinsic and microenvironment-derived survival signals. The pharmacodynamics of cerdulatinib, a dual SYK/JAK inhibitor, and associations with tumor response were investigated.

Patients And Methods: In a phase I dose-escalation study in adults with relapsed/refractory B-cell malignancies, cerdulatinib was administered orally to sequential dose-escalation cohorts using once-daily or twice-daily schedules.

Investigation of lateral geniculate nucleus volume and diffusion tensor imaging in patients with normal tension glaucoma using 7 tesla magnetic resonance imaging.

Background: There is evidence that glaucoma is a neurodegenerative disease involving the whole visual pathway. We prospectively examined potential benefits of volumetry of the lateral geniculate nucleus (LGN) and diffusion tensor imaging (DTI) using a new 7T scanner.

Methods: 20 patients with normal tension glaucoma and 16 control individuals were examined.

The Role of Retinal Vascular Density as a Screening Tool for Ageing and Stroke.

Objectives: To measure the density of retinal vessels from digitized fundus photographs in patients with recent stroke and age-matched controls. To investigate whether the parameter retinal vascular density (RVD) served as a quantitative marker for cerebrovascular events.

Methods: Digitized fundus photographs of n = 158 subjects with stroke or transient ischemic attack within 1 year at the time of examination and n = 1,250 age-matched controls without any remarkable medical history were examined.

Retinal vascular resistance in arterial hypertension.

Purpose: Retinal microcirculation represents an easily accessible, non-invasive, in-vivo possibility to assess early microvascular changes. In addition to the assessment of functional (e.g.

No-reference quality index for color retinal images.

Retinal image quality assessment (RIQA) is essential to assure that the images investigated by ophthalmologists or automatic systems are suitable for reliable medical diagnosis. Measure-based RIQA techniques have several advantages over the more commonly used binary classification-based RIQA methods. Numeric quality measures can aid ophthalmologists in associating a degree of confidence to the diagnosis performed through the investigation of a certain retinal image.

Repetitive dynamic stereo test improved processing time in young athletes.

Background: Current studies revealed the importance of perceptual training for the treatment of amblyopia. To improve stereo vision on a higher level, visual tasks have to be completed within a limited time window like in repetitive visual function tests. "Processing time" as the reaction time in which the absence or presence of depth was identified correctly, is of better predictive value for perceiving the depth than the stereo threshold only.