Publications by authors named "Michelli da Silva Diniz"
Cardiac iron overload evaluation in thalassaemic patients using T2* magnetic resonance imaging following chelation therapy: a multicentre cross-sectional study.
Eduardo Cerello Chapchap Murilo Marques Almeida Silva Reijane Alves de Assis Lucila Nassif Kerbauy Michelli da Silva Diniz
Hematol Transfus Cell Ther
May 2021
Article Synopsis
- The study investigates the effectiveness of MRI T2* in measuring iron levels in thalassaemic patients' organs, focusing on the heart, liver, and pancreas during chelation therapy.
- A total of 136 major thalassaemic patients, with a median age of 18, were analyzed, revealing that iron overload primarily affects the liver (99%) and the pancreas (74%), while the heart is less impacted (36%).
- Results showed a significant reduction in heart iron levels after 1.2 years of therapy, and a strong predictive model for assessing cardiac siderosis was developed based on MRI and ferritin levels.
Unlabelled: ABSTRACTObjectives:To evaluate the use of magnetic resonance imaging in patients with β-thalassemia and to compare T2* magnetic resonance imaging results with serum ferritin levels and the redox active fraction of labile plasma iron.
Methods: We have retrospectively evaluated 115 chronically transfused patients (65 women). We tested serum ferritin with chemiluminescence, fraction of labile plasma iron by cellular fluorescence and used T2* MRI to assess iron content in the heart, liver, and pancreas.