Modeling the effects of prebiotic interventions on luminal and mucosa-associated gut microbiota without and with challenge .

Prebiotics can modulate the gut microbial community composition and function for improved (gut) health and increase resilience against infections. models of the gut facilitate the study of intervention effects on the gut microbial community relevant to health. The mucosa-associated gut microbiota, which thrives in close contact with the host plays a pivotal role in colonization resistance and health.

The vulvar microbiome in lichen sclerosus and high-grade intraepithelial lesions.

Background: The role of the vulvar microbiome in the development of (pre)malignant vulvar disease is scarcely investigated. The aim of this exploratory study was to analyze vulvar microbiome composition in lichen sclerosus (LS) and vulvar high-grade squamous intraepithelial lesions (HSIL) compared to healthy controls.

Methods: Women with vulvar lichen sclerosus ( = 10), HSIL ( = 5) and healthy controls ( = 10) were included.