Publications by authors named "Michelle Y Lu"
Article Synopsis
- This study analyzed cesarean delivery rates and their reasons at a specific hospital between 2013 and 2018, focusing on the impact of updated guidelines from major medical organizations.
- Over the five years, out of nearly 25,000 births, 32.6% resulted in cesarean deliveries, with rates fluctuating but overall trending downward over time.
- For first-time mothers (nulliparous patients), cesarean rates also varied, with a notable decrease and eventual increase by 2018, while the reasons for cesareans showed little change except for cases of nonreassuring fetal status.
Background: A risk-based institutional protocol for inpatient heparin-based venous thromboembolism prophylaxis in a general obstetrical population previously demonstrated a greater than 2-fold increase in wound hematomas with no change in the frequency of thromboembolism.
Objective: We sought to compare the rates of thromboembolism and bleeding outcomes in patients at the highest risk for thromboembolism (eg, those with a history of thromboembolism or thrombophilia who require anticoagulation prophylaxis or therapy throughout pregnancy) than low-risk patients.
Study Design: We performed a retrospective cohort study of all deliveries >20 weeks at a single center from 2013-2018.
Operative vaginal delivery as an independent risk factor for maternal postpartum infectious morbidity.
Am J Obstet Gynecol MFM
November 2022
Background: A recent study from the United Kingdom suggested that a single dosage of adjunctive amoxicillin/clavulanic acid with operative vaginal delivery reduces maternal infectious morbidity by 40% (from 19% to 11%). However, 89% of their study population received an episiotomy.
Objective: This study aimed to evaluate whether operative vaginal delivery is an independent risk factor for composite maternal postpartum infectious morbidity in a population with a low episiotomy rate.
Article Synopsis
- The objective of the study was to assess the effects of a risk-stratified heparin-based thromboprophylaxis protocol before and after its implementation in obstetric patients from 2013 to 2018.
- Results showed no significant difference in rates of postpartum venous thromboembolism (VTE) between the preprotocol and postprotocol groups, despite a substantial increase in the use of heparin-based prophylaxis.
- However, the postprotocol group experienced higher rates of wound hematomas, unplanned surgical procedures, and blood transfusions, suggesting that implementing this strategy may lead to more complications without reducing VTE rates, prompting a reevaluation of the guidelines.
Many natural biological systems--such as biofilms, shells and skeletal tissues--are able to assemble multifunctional and environmentally responsive multiscale assemblies of living and non-living components. Here, by using inducible genetic circuits and cellular communication circuits to regulate Escherichia coli curli amyloid production, we show that E. coli cells can organize self-assembling amyloid fibrils across multiple length scales, producing amyloid-based materials that are either externally controllable or undergo autonomous patterning.
View Article and Find Full Text PDFSialic acid can improve qualities of therapeutic glycoproteins such as circulatory half-life, biological activity, and solubility. In production of therapeutic glycoproteins, a high-throughput method is required for process monitoring and optimization to ensure consistent and optimal sialic acid content. Current methods for quantifying sialic acid, however, require chromatographic separation that is time-consuming and cannot rapidly analyze many samples in parallel.
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