MiR-410-3p suppresses primary gastric cancer and exosomes regulate endogenous expression of miR-410-3p.

MicroRNAs play significant roles in cancer initiation and progression. Exosomes are important extracellular vesicles for transporting molecules to distant sites. This study aims to investigate the functional roles of miR-410-3p in primary gastric cancer, as well as the roles of exosomes in regulating expression of miR-410-3p.

Inhibition of EP2 receptor suppresses tumor growth and chemoresistance of gastric cancer.

Gastric cancer is one of the leading causes of cancer death in the world. Early diagnosis and effective chemotherapy are vital to reduce the overall mortality. Prostaglandin E2 (PGE2) has been implicated as an important factor in gastric cancer carcinogenesis.

Methylation-associated silencing of promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways.

Human growth factor receptor-bound protein-7 (GRB7) is a pivotal mediator involved in receptor tyrosine kinase signaling and governing diverse cellular processes. Aberrant upregulation of GRB7 is frequently associated with the progression of human cancers. However, the molecular mechanisms leading to the upregulation of GRB7 remain largely unknown.