Report of Prolonged Neonatal Hypoglycemia in Three Infants of Mothers With Variants in .

Background/objective: Genetic variants in hepatic nuclear factor 1α () cause maturity-onset diabetes of the young (MODY). We sought to examine whether MODY variants also cause neonatal hypoglycemia.

Case Report: We present 3 infants with variants in shared with their mothers.

Temozolomide in the treatment of an invasive prolactinoma resistant to dopamine agonists.

Prolactinomas are common tumors of the anterior pituitary gland. While conventional therapies, including dopamine agonists, transsphenoidal surgery and radiotherapy, are usually effective in controlling tumor growth, some patients develop treatment-resistant tumors. In this report, we describe a patient with an invasive prolactinoma resistant to conventional therapy that responded to the administration of the alkylating agent, temozolomide.