Improving Pediatric Adverse Drug Event Reporting through Clinical Pharmacy Services.

Objectives: The purpose of this study was to summarize adverse drug event (ADE) reporting and to characterize the type of healthcare practitioners involved in reporting over a 10-year period at a 120-bed university-affiliated children's hospital.

Methods: The University of Virginia Children's Hospital ADE database was analyzed for records involving pediatric patients. Data from patients <18 years of age who were admitted to the University of Virginia Children's Hospital between January 1, 2000, and December 31, 2009, were analyzed.

Zoster vaccine live.

Herpes zoster is a neurocutaneous disease caused by the varicella-zoster virus and is associated with significant morbidity and long-term sequelae in older adults. Until recently, treatment options for these complications have been primarily targeted at disease state management and symptom relief. Zoster vaccine live is the first vaccine approved for the prevention of herpes zoster.

Trivalent intranasal influenza vaccine, live.

Objective: To review human data on the efficacy, safety, and clinical use of trivalent intranasal influenza vaccine, live (TIIVL).

Data Sources: A MEDLINE search (1966-3rd week of January 2004) using the terms influenza vaccine, intranasal administration, and FluMist was conducted. References from pertinent articles were also reviewed.

Excessive somnolence from aripiprazole in a child.

A 9-year-old girl was hospitalized with prolonged somnolence that began 3.5 hours after a single 15-mg dose of aripiprazole. After extensive workup, physical examinations were unremarkable, and all laboratory test results were within normal limits.

Possible anaphylaxis after propofol in a child with food allergy.

Objective: To report a case of anaphylaxis due to propofol in a child with allergies to egg and peanut oil.

Case Summary: A 14-month-old boy with a history of reactive airway disease was hospitalized for treatment of respiratory symptoms. The patient had documented allergies to egg, peanut oil, and mold.

Clopidogrel-associated leukopenia.

Objective: To report a case of leukopenia in a patient receiving clopidogrel following intracoronary stent placement.

Case Summary: A 58-year-old white man presented to the emergency department (ED) with fever and chills. Seven days prior to presentation, he underwent intracoronary stent placement and clopidogrel 75 mg once daily was initiated.