Clozapine monitoring at a specialised psychiatric hospital: A retrospective chart review.

Background: Clozapine is the only Food and Drug Administration (FDA) and National Institute for Care and Excellence (NICE) approved drug for treatment-resistant schizophrenia (TRS). Its potentially life-threatening haematological side effects of neutropaenia and agranulocytosis mandate rigorous monitoring of neutrophil counts, presenting unique, Third-World population challenges.

Aim: To describe the Clozapine white blood cell monitoring practice and outcomes in a local psychiatric hospital.